Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,391-1,400 of 2,298 results
Stem Cell Research & Therapy, 2024 • October 14, 2024
The combination of LOCAS and iPSCs-NSCs demonstrated a positive therapeutic impact on motor function recovery and tissue repair in rats with SCI. LOCAS combined with iPSCs-NSCs showed a good therapeut...
KEY FINDING: After 12 weeks, rats in the LOCAS-iPSCs-NSCs group exhibited significantly higher BBB scores (8.6) compared to the LOCAS-iPSCs-NSCs group (5.6) and the Model group (4.2).
International Journal of Nanomedicine, 2024 • October 19, 2024
In this study, we innovatively constructed a nanocomplex to achieve more effective repair after spinal cord injury. Through in vitro and in vivo experiments, we found that this biomaterial can effecti...
KEY FINDING: Achieving nerve growth factors sustained release, GMNF had good biocompatibility and could effectively penetrate into the cells with good targeting permeability.
bioRxiv preprint, 2024 • October 19, 2024
The study confirms that uninjured, regenerative stage Xenopus tropicalis tadpoles maintain expression of developmental markers of D/V NPC domains, and demonstrates that these domains are present durin...
KEY FINDING: Neural progenitor markers Msx1/2, Nkx6.1, and Nkx2.2 are confined to dorsal, intermediate and ventral spatial domains, respectively, in both the uninjured and regenerating spinal cord.
Neurotrauma Reports, 2024 • January 1, 2024
The study investigated the neuroprotective potential of inosine in a mouse model of compressive spinal cord injury (SCI). Inosine was administered intraperitoneally after SCI, and its effects on behav...
KEY FINDING: Inosine treatment resulted in greater preservation of white matter in the spinal cord, as evidenced by immunostaining for oligodendrocytes and the number of myelinated fibers.
Skeletal Muscle, 2024 • October 20, 2024
The study compared the regenerative response of Acomys and Mus to VML injuries in the tibialis anterior (TA) muscle. Contrary to expectations based on Acomys' regenerative capabilities in other tissue...
KEY FINDING: Neither Acomys nor Mus recovered lost muscle mass or myofiber number within three months following VML injury, and Acomys also failed to recover force production better than Mus.
International Journal of Surgery, 2024 • November 5, 2024
Stem-cell therapy is a revolutionary frontier in modern medicine, offering enormous capacity to transform the treatment landscape of numerous debilitating illnesses and injuries. Stem cells’ regenerat...
KEY FINDING: Stem cell therapy offers unprecedented potential to address a wide range of debilitating diseases and injuries.
Neural Regen Res, 2025 • September 6, 2024
Olfactory receptors, traditionally recognized for their role in detecting volatile compounds, have been found to have broader functional implications in numerous non-olfactory tissues. Ectopic OR expr...
KEY FINDING: Olfactory receptors are crucial for detecting odors and influencing behaviors from food choices to emotional memories, and have potential applications in medical diagnostics and environmental monitoring.
Cell Reports Methods, 2024 • November 18, 2024
The study developed a method to induce human embryonic stem cells to produce self-renewing NMPs (srNMPs) under chemically defined conditions. These srNMPs can generate mesodermal cells and neurons, ev...
KEY FINDING: srNMPs can be generated and maintained under chemically defined conditions for long-term passage.
Int. J. Mol. Sci., 2024 • October 29, 2024
This review explores the regenerative capacity of Xenopus laevis, focusing on tail regeneration, as a model to uncover cellular, molecular, and developmental mechanisms underlying tissue repair. The r...
KEY FINDING: Regeneration-organizing cells (ROCs) are essential for tail regeneration. They migrate to the amputation plane and secrete ligands like TGFβ, FGFs, BMPs, and Wnts that promote proliferation in progenitor cells.
Bioeng Transl Med, 2024 • May 1, 2024
This study investigates the efficacy of photobiomodulation (PBM) in promoting neuroregeneration and functional recovery after spinal cord injury (SCI) using both implantable (iPBM) and transcutaneous ...
KEY FINDING: Optimal neuroprotection in vitro was achieved with PBM between 4 and 22 mW/cm2, with 11 mW/cm2 for 1 min per day (0.66 J/cm2) increasing cell viability by 45% and neurite outgrowth by 25%.