Evi5 is required for Xenopus limb and tail regeneration

This study investigates the role of Evi5, a protein upregulated during limb regeneration in axolotls, in Xenopus tadpoles' limb and tail regeneration. It was found that Evi5 is also upregulated in Xenopus tadpoles during regeneration. The researchers found that reducing Evi5 levels impairs limb development and blastema formation, a critical step in regeneration. This suggests that Evi5 is important for cell proliferation and survival during limb regeneration. Further analysis revealed that Evi5 affects the expression of other genes involved in regeneration, specifically Kdm6b and Kdm7a. The knockdown of these genes also results in defective limb regeneration, which indicates their importance.

• 1
  Evi5 is upregulated during limb and tail regeneration in Xenopus tadpoles, similar to its role in axolotls.
• 2
  Knocking down Evi5 inhibits limb development and blastema formation in Xenopus tadpoles.
• 3
  Evi5 knockdown downregulates lysine demethylases Kdm6b and Kdm7a, which are also required for limb regeneration.