Regenerative Medicine Research

KEY FINDING: DOCK2 regulates immunosuppressive function in human stromal cell models.

KEY FINDING: The review identifies various molecular pathways activated after nerve injury, such as cAMP, MAPK, and RhoA/ROCK/LIMK, as significant in axonal regeneration.

KEY FINDING: Electrospun PLLA scaffolds, especially those with aligned nanofibers, promote nerve cell proliferation, guide neurite extension, and modulate macrophage polarization towards anti-inflammation.

KEY FINDING: Radial glial cells (RGCs) or radial glia-like cells (RGLCs) have been documented in adults of various species, where functions, additional to their embryological role, have been described.

KEY FINDING: Rassf7a promotes spinal cord regeneration in zebrafish. Zebrafish larvae with a rassf7a mutation exhibit defects in spinal cord regeneration and spinal neurogenesis.

KEY FINDING: Myostatin b (mstnb) is dynamically expressed in dorsal spinal cord progenitors after injury in zebrafish.

KEY FINDING: Early surgical decompression (<24 h) resulted in better neurological recovery compared to late surgery (≥24 h) in cervical SCI patients.

KEY FINDING: 3D GM scaffolds demonstrate suitable biocompatibility, biodegradation, and porosity, offering a cost-effective and easily produced solution.

KEY FINDING: Enzymatic digestion yields higher cell numbers more rapidly compared to explant culture-based methods.

KEY FINDING: MHC-I upregulation peaks at 7 days postinjury in both C57BL/6J and A/J mice, but is significantly higher in the A/J strain.