A Comparative Study of Mesenchymal Stem Cell-Derived Extracellular Vesicles’ Local and Systemic Dose-Dependent Administration in Rat Spinal Cord Injury

Spinal cord injury is a serious condition leading to severe disability, and this study explores a cell-free therapy using microvesicles from stem cells for neuroregeneration. The study found that motor activity was higher in experimental groups treated with microvesicles compared to control groups, indicating improved recovery. Intravenous administration of microvesicles yielded better results, with motor function recovery increasing more than two times compared to the control group.

• 1
  Intravenous administration of MSC-EVs showed a higher success rate in improving motor function of hindlimbs compared to local administration.
• 2
  MSC-EVs had a positive effect on motor parameters of the nervous system, both central and peripheral, with higher doses showing superiority.
• 3
  MSC-EV therapy increased the number of mature Olig2+ cells in the white matter of the spinal cord, indicating stimulation of nerve fiber myelination.