Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,101-1,110 of 2,298 results
AAAS Research, 2022 • August 3, 2022
This study compared different therapeutic agents and configurations for spinal cord injury repair, including collagen and Matrigel scaffolds, bead assembly and bulk gel configurations, and cell-laden ...
KEY FINDING: Matrigel-based agents and cerebral organoid transplantations resulted in more axon regeneration and higher BBB scoring compared to collagen gels.
Frontiers in Pharmacology, 2024 • August 6, 2024
This editorial provides an overview of the current research landscape regarding advanced neural stem cell therapies for spinal cord injury (SCI). It summarizes key articles published on the topic, hig...
KEY FINDING: Stem cell therapy, particularly using Mesenchymal Stem Cells (MSCs) and Neural Stem Cells (NSCs), shows promise for treating SCI, although firm evidence of a cure is lacking.
Materials Today Bio, 2022 • August 18, 2022
This study introduces Spinor, a developmentally engineered bio-assembly of DPMSCs, designed to mimic spinal cord structure and function as an exosome delivery system. Spinor releases exosomes with enh...
KEY FINDING: DPMSC-derived exosomes are more effective in promoting nerve regeneration compared to exosomes from other MSC sources like umbilical cord and bone marrow.
J. Pers. Med., 2022 • September 10, 2022
The discovery of iPSCs has provided a new roadmap for clinical translation research and regeneration therapy. The role of human iPSCs in scientific research was examined and the most common neurodegen...
KEY FINDING: Parkinson’s disease scored highest in iPSC-related research publications, followed by Alzheimer’s disease, based on a PUBMED literature review.
Pharmaceutics, 2022 • September 2, 2022
This study investigates the molecular effects of a single subcutaneous high-dose G-CSF application upon different regions of the rodent brain. The study reveals minor suppressive or stimulatory effect...
KEY FINDING: G-CSF generally downregulates neurogenic differentiation markers in most brain regions studied.
Frontiers in Molecular Neuroscience, 2022 • September 7, 2022
This review focuses on the unique advantages of using zebrafish larvae as a model for studying spinal cord regeneration, emphasizing their optical transparency, simple anatomy, and complex locomotor b...
KEY FINDING: Spinal cord regeneration in zebrafish larvae is distinct from development, with injury-dependent responses such as immune cell infiltration and glial bridge formation.
Nature Communications, 2022 • September 23, 2022
The study presents a single-cell atlas of the lumbar spinal cord after thoracic spinal cord injury in mice, detailing cell type-specific responses across acute, subacute, and chronic stages. The resea...
KEY FINDING: Rare spinal neurons, particularly spinocerebellar projection neurons, express a signature of regeneration in response to spinal cord injury.
Annals of Translational Medicine, 2022 • September 1, 2022
This study investigates the effects of decellularization on the microenvironment of injured spinal cords and its potential to promote neurite outgrowth. The researchers found that decellularization re...
KEY FINDING: The expression of ECM components (collagen type I and IV, fibronectin, and laminin) increased with SCI progression, peaking at 14 days post-injury.
Neurospine, 2022 • September 1, 2022
This review aims to describe the involvement of ECM components in the remodeling process of spinal cord injury (SCI) and intervertebral disc degeneration (IVDD). SCI leads to damage to the intact ECM...
KEY FINDING: ECM components demonstrate both regenerative and degenerative potential in the central nervous system.
Stem Cell Research & Therapy, 2022 • January 1, 2022
This research explores the potential of adipose-derived mesenchymal stem cell (ADSC) sheets to treat neurogenic bladder (NB) associated with spinal cord injury (SCI). The study uses a rat model of SCI...
KEY FINDING: ADSC sheet transplantation increased the number of nerve fibers and decreased glial scar formation at the injury site in the spinal cord.