Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,091-1,100 of 2,298 results
Cells, 2022 • July 27, 2022
This study investigates retrograde signals that trigger regeneration or cell death after axotomy in the CNS, focusing on local protein synthesis in axon tips. Single-cell RNA-seq was performed on micr...
KEY FINDING: Genes were identified that were upregulated selectively in growing (n = 38), static (20) or retracting tips (18). Among them, map3k2, csnk1e and gtf2h were expressed in growing tips, mapk8(1) was expressed in static tips and prkcq was expressed in retracting tips.
Stem Cell Research & Therapy, 2022 • August 3, 2022
This study investigates the therapeutic potential of intra-amniotic transplantation of brain-derived neurotrophic factor (BDNF)-modified bone marrow mesenchymal stem cells (BMSCs) for rat fetuses with...
KEY FINDING: BDNF-BMSCs sustained the characteristic of directional migration, engrafted at the SBA lesion area, increased the expression of BDNF in the defective spinal cords, alleviated the apoptosis of spinal cord cells, differentiated into neurons and skin-like cells, reduced the area of skin lesions, and improved the amniotic fluid microenvironment.
Molecular Medicine, 2022 • August 3, 2022
The study investigates the therapeutic potential of modulating neuronal activity in sensory and motor neurons, using opto- and chemogenetic stimulation, to regulate axonal growth after injury. Results...
KEY FINDING: Optogenetic stimulation of DRG neurons increases axonal growth in vitro.
J Neurosci Res, 2022 • November 1, 2022
The study investigates axonal regeneration and functional recovery in a larval zebrafish model of spinal cord injury (SCI). Researchers developed open-source software to measure zebrafish lateral trun...
KEY FINDING: Spinal cord transection in larval zebrafish caused a significant reduction in axial movements caudal to the lesion site, indicating motor paralysis.
ACS Nano, 2022 • August 24, 2022
This review provides an overview of spinal cord injury (SCI) characteristics and pathophysiology, discusses ongoing clinical trials targeting SCI, and introduces the role of graphene-based materials (...
KEY FINDING: GBMs can promote neural stem cells (NSCs) survival and differentiation.
Neural Regeneration Research, 2023 • March 1, 2023
This review discusses the changes in Noggin expression during spinal cord injury (SCI), its neuroprotective role in preclinical models, and the knowledge gap for its use in SCI treatment. The neuropro...
KEY FINDING: Noggin shows neuroprotective effects in the early phase of SCI in both in vitro and in vivo models following exogenous Noggin treatment, as well as in SCI in vivo models following therapy with engineered Noggin-expressing cells or implants.
Dev Cell, 2024 • February 26, 2024
The study dissects macrophage phenotypes in spiny mice (Acomys spp.) that regenerate ear pinnae tissue versus lab mice (Mus musculus) that form scar tissue, identifying secreted factors from activated...
KEY FINDING: Acomys macrophages exhibit a muted inflammatory profile compared to Mus macrophages and secrete factors that antagonize collagen production and drive matrix remodeling.
Neural Regeneration Research, 2023 • March 1, 2023
This study investigates the role of DUSP2, a phosphatase, in axon regeneration of Mauthner cells (M-cells) in zebrafish after spinal cord injury. The researchers used CRISPR/Cas9 to knock out the dusp...
KEY FINDING: DUSP2 knockout in zebrafish promotes M-cell axon regeneration at an early stage after birth (within 8 days).
Tissue Eng Regen Med, 2022 • August 29, 2022
This study investigated the efficacy and safety of transplanting human polysialylated-neural cell adhesion molecule (PSA-NCAM)-positive neural precursor cells (hNPCsPSA-NCAM?) into rats with spinal co...
KEY FINDING: Transplantation of hNPCsPSA-NCAM? into injured spinal cords of rats significantly improved locomotor function.
The Journal of Biomedical Research, 2022 • June 28, 2022
Spinal cord injury (SCI) leads to permanent deficits in neural function without effective therapies, which places a substantial burden on families and society. During the past three decades, astrocyte...
KEY FINDING: Rodent astrocytes can survive, move, and mature in spinal injuries, reduce scar formation, encourage axon regeneration, and improve motor, sensory, breathing, and autonomic functions.