Regenerative Medicine Research

KEY FINDING: Knocking out NF-1 in NSCs enhances their anti-apoptotic ability in vitro, protecting them from cell death.

KEY FINDING: Magnetic Resonance Imaging (MRI), including functional MRI (fMRI) and microstructural MRI, is used for morphological assessment, lesion volumetry, and evaluation of the blood-spinal-cord-barrier integrity.

KEY FINDING: Clemastine enhances oligodendrocyte differentiation and myelination, which helps to delay axonal degeneration and promote motor function recovery in rat SCI models.

KEY FINDING: The neuronal diversity in the salamander brain is unexpectedly high, with studies identifying numerous clusters of glutamatergic and GABAergic neurons, suggesting a greater complexity than previously thought.

KEY FINDING: The SP-immobilized multiple microchannels aligned the regrowth of nerve fibres and recruited the host stem cells, which enhanced the functional regeneration capacity.

KEY FINDING: In vitro, expanded hfNPCs retained neural features, multipotency, and self-renewal, which supported the development of a cell banking strategy.

KEY FINDING: AST-FC combined therapy effectively alleviated oxidative stress and the inflammatory response in the acute phase of BPA.

KEY FINDING: The grooved GelMA-MXene hydrogel promotes neural stem cell adhesion, proliferation, and differentiation in vitro.

KEY FINDING: Neurospheres can be generated from both brain- and spinal cord-derived cells of post-metamorphic P. waltl using a standard neurosphere culture method.

KEY FINDING: Skeletal regeneration is sexually dimorphic: female mice require estrogen for skeletal stem cell-mediated bone regeneration, while male mice do not exhibit similar estrogen responsiveness.