Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 41-50 of 321 results
Proteins: Structure, Function, and Bioinformatics, 2025 • January 1, 2025
This study demonstrates that valacyclovir and acyclovir, commonly used antiviral drugs, are substrates of the enzyme cypin, which deaminates these compounds. The research uses NADH-coupled assays, try...
KEY FINDING: Valacyclovir and acyclovir are deaminated by cypin, meaning cypin breaks them down.
Neural Regen Res, 2023 • July 1, 2023
This review summarizes the important metabolic pathways involved in SCI as well as the importance of enolase activity on the cell surface following SCI. Interaction at the cell surface allows enolase ...
KEY FINDING: Enolase promotes both pro- and anti-inflammatory events and regulates functional recovery in SCI.
J. Proteome Res., 2022 • May 4, 2022
This study aimed to improve understanding of spinal cord injury pathology by examining glycosylation changes following injury in both rat and Xenopus models. The researchers investigated how an aligne...
KEY FINDING: Following SCI in rats, complex and outer-arm fucosylated glycans decreased, while oligomannose and hybrid structures increased.
Neural Regeneration Research, 2023 • September 1, 2023
The review focuses on the role of matrix metalloproteases (MMPs) in spinal cord injury (SCI) and the potential of MMP inhibitors as a therapeutic strategy. MMPs contribute to several detrimental proce...
KEY FINDING: MMP-9 and MMP-2 are upregulated after SCI, contributing to BSCB breakdown, inflammation, and apoptosis.
The Journal of Neuroscience, 2019 • March 13, 2019
This study establishes a workflow template from cell culture to animals in which microtubule-based treatments can be tested for their effectiveness in augmenting regeneration of injured axons relevant...
KEY FINDING: Knockdown of fidgetin resulted in faster-growing axons on both laminin and aggrecan and enhanced crossing of axons from laminin onto aggrecan in vitro.
European Journal of Neuroscience, 2025 • February 1, 2025
The study investigates the effects of extremely low-frequency and low-intensity electromagnetic fields (ELF-EMF) on microtubules (MTs) and Tau-MT interactions in a neuronal cell model exposed to zinc ...
KEY FINDING: Timed pre-exposure to ELF-EMF (40 Hz, 1 G) enhanced microtubule dynamics, specifically increasing EB1 comet tracks' length with a 10 min (48 h) treatment.
Biophysical Reviews, 2024 • October 5, 2023
New optical techniques in neuroscience advance understanding of neurological conditions. They show potential in unraveling processes and evaluating therapies for spinal cord injury, peripheral nerve i...
KEY FINDING: Coherent Raman scattering and third harmonic generation enable label-free visualization of myelin sheaths. Combining these with two-photon excited autofluorescence and second harmonic generation allows comprehensive tissue visualization.
Asian Spine Journal, 2015 • February 1, 2015
This study examined the expression of Hyal-4 in a rat spinal cord hemisection model to understand its role in CSPG degradation after injury. The results showed that CSPGs peaked at 3 weeks post-injury...
KEY FINDING: CSPGs appeared at the injury site at 4 days after hemisection, reached a peak after 3 weeks, and then decreased.
Anat Rec (Hoboken), 2012 • October 1, 2012
This study provides a histological comparison of the mature regenerated and original tail of the lizard Anolis carolinensis. The regenerated tail has a cartilage skeleton enclosing a spinal cord but l...
KEY FINDING: The regenerated tail has a cartilage tube with foramina, enclosing a spinal cord with an ependymal core, but no regeneration of dorsal root ganglia or peripheral nerves.
Glia, 2008 • January 15, 2008
This study investigates the role of NG2, a chondroitin sulfate proteoglycan, in tPA-mediated plasmin generation and its implications for spinal cord injury recovery. The findings indicate that NG2 act...
KEY FINDING: NG2 binds to both tPA and plasminogen, accelerating the conversion of plasminogen to plasmin.