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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Physiology Research

Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.

Showing 31-40 of 321 results

PhysiologyTrauma

Decompression illness: a comprehensive overview

Diving and Hyperbaric Medicine, 2024 • March 31, 2024

Decompression illness is a collective term for two maladies (decompression sickness [DCS] and arterial gas embolism [AGE]) that may arise during or after surfacing from compressed gas diving. Bubbles ...

KEY FINDING: DCS is caused by bubble formation from dissolved inert gas during or after a reduction in ambient pressure (‘decompression’). Relevant decompressions may occur on ascent from an underwater dive, exiting a pressurised workspace, ascent to high altitude in an unpressurised aircraft, and during extravehicular activity in space.

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PhysiologyNeurology

Chemogenetic stimulation of phrenic motor output and diaphragm activity

bioRxiv preprint, 2024 • November 13, 2024

The study investigated whether expressing designer receptors exclusively activated by designer drugs (DREADDs) in the mid-cervical spinal cord could stimulate phrenic motor output to increase diaphrag...

KEY FINDING: DREADD ligand JHU37160 (J60) caused a bilateral, sustained (>1 hour) increase in inspiratory EMG bursting in both wild-type and ChAT-Cre mice, with a greater relative increase in ChAT-Cre mice.

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Spinal Cord InjuryPhysiologyRehabilitation

Rib cage contributions to inspiratory capacity in patients with cervical spinal cord injury

Current Research in Physiology, 2024 • May 17, 2024

This study investigated the influence of rib cage motion on inspiratory capacity (IC) in patients with cervical spinal cord injury (CSI) using respiratory inductance plethysmography (RIP). The finding...

KEY FINDING: A significant correlation was observed between inspiratory capacity (IC) and rib cage motion (VRIP-rc) (r = 0.67, p = 0.02), indicating that rib cage motion significantly influences IC in CSI patients.

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Spinal Cord InjuryPhysiologyBiomedical

Biochemical Monitoring of Spinal Cord Injury by FT-IR Spectroscopy—Effects of Therapeutic Alginate Implant in Rat Models

PLoS ONE, 2015 • November 11, 2015

This study employed FT-IR spectroscopic imaging to evaluate the therapeutic impact of nonfunctionalized soft Ca2+-alginate hydrogel implants in a rat model of SCI. The results showed that alginate sig...

KEY FINDING: Alginate implants significantly reduced injury-induced demyelination of the contralateral white matter in the chronic state after SCI.

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Spinal Cord InjuryRegenerative MedicinePhysiology

The Protein Acetylation after Traumatic Spinal Cord Injury: Mechanisms and Therapeutic Opportunities

International Journal of Medical Sciences, 2024 • February 12, 2024

This review summarizes the role of protein acetylation in spinal cord injury (SCI), highlighting the involvement of histone and non-histone acetylation in regulating neuron growth and axonal regenerat...

KEY FINDING: Histone acetylation influences neural plasticity, synaptogenesis, and synaptic plasticity, impacting tissue remodeling post-SCI. Specifically, H4 acetylation levels are time-related and affect glial fibrillary acidic protein levels.

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Spinal Cord InjuryPhysiologyNeurology

Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC

ACS Omega, 2021 • April 19, 2021

This study characterizes the activity of a genetically modified chondroitinase ABC enzyme (mChABC) and compares it to the bacterial enzyme (bChABC) under physiologically relevant conditions. The resul...

KEY FINDING: mChABC is secreted robustly from mammalian cells without altering its functional activity compared to bChABC, maintaining optimal activity on chondroitin sulfate-A at pH 8.0 and 37°C.

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Spinal Cord InjuryPhysiologyNeurology

Glutathione effect on functional and histological recovery after spinal cord injury in rats

Clinics, 2024 • January 1, 2024

This study investigated the effect of glutathione (GSH) on functional and histological recovery after experimental spinal cord injury in rats. Forty Wistar rats were subjected to spinal cord injury an...

KEY FINDING: Rats treated with GSH showed statistically significant improvement in locomotor function based on the BBB scale compared to the saline solution group.

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Spinal Cord InjuryRegenerative MedicinePhysiology

Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability

Dev Biol, 2011 • July 15, 2011

This study identifies PAD3 as a developmentally-regulated enzyme expressed both in progenitors and mature neural cells that appears to be an important player in the early spinal cord injury response a...

KEY FINDING: PAD3 expression increases with development and is further upregulated after spinal cord injury, particularly at stages when regeneration is less effective.

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Spinal Cord InjuryPhysiologyNeurology

Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury

MOLECULAR MEDICINE REPORTS, 2019 • January 1, 2019

The study investigates the effect of low-frequency pulsed electromagnetic fields (LPEMFs) on spinal cord injury (SCI) in rats, focusing on inflammation, oxidative stress, and HSP70 levels. Results sho...

KEY FINDING: LPEMFs significantly promoted functional recovery following spinal cord injury, as demonstrated by an increased Basso, Beattie and Bresnahan score.

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Spinal Cord InjuryPhysiologyNeurology

Expression Profile of Flotillin-2 and its Pathophysiological Role after Spinal Cord Injury

J Mol Neurosci, 2013 • February 1, 2013

This study investigates the spatio-temporal profile of Flotillin-2 (Flot-2) expression in adult rats after spinal cord injury (SCI) and its role in locomotor recovery. The results indicate that SCI in...

KEY FINDING: SCI produced a significant decrease in the level of Flot-2 at 2 days post-injury (DPI) that increased until 28 DPI.

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