Physiology Research

KEY FINDING: DCS is caused by bubble formation from dissolved inert gas during or after a reduction in ambient pressure (‘decompression’). Relevant decompressions may occur on ascent from an underwater dive, exiting a pressurised workspace, ascent to high altitude in an unpressurised aircraft, and during extravehicular activity in space.

KEY FINDING: DREADD ligand JHU37160 (J60) caused a bilateral, sustained (>1 hour) increase in inspiratory EMG bursting in both wild-type and ChAT-Cre mice, with a greater relative increase in ChAT-Cre mice.

KEY FINDING: A significant correlation was observed between inspiratory capacity (IC) and rib cage motion (VRIP-rc) (r = 0.67, p = 0.02), indicating that rib cage motion significantly influences IC in CSI patients.

KEY FINDING: Alginate implants significantly reduced injury-induced demyelination of the contralateral white matter in the chronic state after SCI.

KEY FINDING: Histone acetylation influences neural plasticity, synaptogenesis, and synaptic plasticity, impacting tissue remodeling post-SCI. Specifically, H4 acetylation levels are time-related and affect glial fibrillary acidic protein levels.

KEY FINDING: mChABC is secreted robustly from mammalian cells without altering its functional activity compared to bChABC, maintaining optimal activity on chondroitin sulfate-A at pH 8.0 and 37°C.

KEY FINDING: Rats treated with GSH showed statistically significant improvement in locomotor function based on the BBB scale compared to the saline solution group.

KEY FINDING: PAD3 expression increases with development and is further upregulated after spinal cord injury, particularly at stages when regeneration is less effective.

KEY FINDING: LPEMFs significantly promoted functional recovery following spinal cord injury, as demonstrated by an increased Basso, Beattie and Bresnahan score.

KEY FINDING: SCI produced a significant decrease in the level of Flot-2 at 2 days post-injury (DPI) that increased until 28 DPI.