Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 51-60 of 321 results
Neural Regeneration Research, 2017 • May 1, 2017
This study explores the dual role of chondroitin sulfate proteoglycans (CSPGs) in neural regeneration, highlighting their potential to switch from inhibitors to promoters of regeneration under specifi...
KEY FINDING: HB-GAM can reverse the inhibitory effect of CSPGs on neurite outgrowth in vitro, promoting growth instead.
Oxidative Medicine and Cellular Longevity, 2021 • September 1, 2021
This study investigates the role of mitochondrial ROS in mechanical stress-induced disc degeneration using a one-strike loading organ culture model. The researchers found that mechanical stress leads ...
KEY FINDING: Mechanical stress induces mitochondrial dysfunction and ROS accumulation in nucleus pulposus (NP) cells. The proportion of ROS-positive cells increased significantly in the first 12 hours after mechanical stress.
Antioxidants, 2022 • November 12, 2022
The study investigated the expression of H2S-metabolizing enzymes in intestinal biopsies from healthy individuals and IBD patients, across different age groups. Immunohistochemical staining was used t...
KEY FINDING: Healthy adults showed a trend towards lower expression of H2S-metabolizing enzymes compared to healthy children, indicating an age-related decrease.
International Journal of Molecular Sciences, 2020 • September 24, 2020
The study screened small organic compounds for their ability to mimic the HNK-1 carbohydrate, which is known to play a role in preferential motor reinnervation after nerve injury. Six compounds were i...
KEY FINDING: Six small organic compounds (ursolic acid, indirubin, tosufloxacin, 5-nonyloxytryptamine, hexachlorophene, and tamoxifen) were identified as HNK-1 mimetics using a competitive ELISA.
Exp Neurol, 2015 • January 1, 2015
The study investigates whether inhibiting kinesin-5 with monastrol can improve axonal regeneration after spinal cord injury (SCI) when combined with ChABC treatment. Monastrol enhanced axonal regenera...
KEY FINDING: Monastrol treatment, combined with ChABC, significantly enhanced axonal regeneration after spinal cord injury in rats.
Chembiochem, 2020 • April 1, 2020
This study demonstrates the ability of OleD Loki to glycosylate a diverse set of HDAC inhibitors, forming hydroxamate glycosyl esters. The resulting glycosylated products exhibited reduced cytotoxicit...
KEY FINDING: OleD Loki can convert a wide range of HDAC inhibitors into their corresponding hydroxamate glycosyl esters.
Frontiers in Neuroscience, 2017 • February 21, 2017
Following damage to the axons of central nervous system (CNS) and peripheral nervous system (PNS) neurons, a number of cellular and molecular processes are initiated to promote regeneration of damaged...
KEY FINDING: HSP27 upregulation and phosphorylation are required for injured sensory and motor neuron survival after sciatic nerve transection.
Scientific Reports, 2023 • October 20, 2023
This study successfully synthesized GO using a modified Hummer's method and immobilized cABC I on it, characterized using XRD, FTIR, and SEM. The immobilized cABC I on GO followed Michaelis-Menten kin...
KEY FINDING: Immobilization of cABC I on GO resulted in a greater Km and lower Vmax compared to the free enzyme.
Analytical and Bioanalytical Chemistry, 2018 • April 18, 2018
Neural progenitor cells were cultured on electrospun P(HB-co-HHx) fiber substrates coated with either laminin or poly-L-lysine/laminin. At different times after cell seeding, the samples were fixed an...
KEY FINDING: Changes in lipid and amide I–II spectral regions are modulated by the type and coating of the substrate used and the culture time.
BMC Neurology, 2009 • July 15, 2009
This study investigates the expression patterns of CSPG family members (NG2, neurocan, versican, and phosphacan) in post-mortem human spinal cord samples after traumatic SCI to understand their role i...
KEY FINDING: NG2 and phosphacan were both detected in the evolving astroglial scar after human SCI, suggesting they might hinder CNS regeneration.