Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 271-280 of 321 results
Exp Neurol, 2013 • September 1, 2013
This study investigates the effectiveness of high-frequency spinal cord stimulation (HF-SCS) to activate the diaphragm in rats with spinal cord injury, comparing it to previous findings in dogs. The r...
KEY FINDING: HF-SCS results in activation of the diaphragm at physiological firing frequencies in rats following spinal cord injury.
J Physiol, 2013 • March 18, 2013
This study examined the effects of transcranial polarization on rubro- and reticulospinal neurons in deeply anaesthetized cats. The results indicate that tDCS facilitates transsynaptic activation of s...
KEY FINDING: Transcranial polarization facilitates transsynaptic activation of both rubrospinal and reticulospinal neurons.
Clin Neurophysiol, 2013 • September 1, 2013
The purpose of this study is to investigate whether muscle activity from synchronous or asynchronous sources is modulated during supra-maximal electrical stimulation and muscle fatigue in humans with ...
KEY FINDING: Fatigue enhanced the activation to the paralyzed soleus muscle, but primarily at the H-reflex latency.
Respir Physiol Neurobiol, 2013 • November 1, 2013
The paper reviews a novel method of inspiratory muscle activation using high-frequency (300 Hz) electrical stimulation on the ventral surface of the upper thoracic spinal cord. Unlike previous methods...
KEY FINDING: High-frequency spinal cord stimulation (HF-SCS) results in synchronous activation of both the diaphragm and inspiratory intercostal muscles in an animal model.
The Journal of Spinal Cord Medicine, 2014 • January 1, 2014
This study investigated the impact of physical exercise on body composition and insulin resistance in individuals with cervical spinal cord injury (c-SCI). The results showed that physically active in...
KEY FINDING: Physically active individuals with c-SCI had significantly lower total fat mass (t-FM) and regional fat mass (r-FM) compared to non-active individuals.
PLoS ONE, 2013 • October 17, 2013
The present study investigated the degree of impairment in crossed corticospinal facilitation in muscles above, at, and below a SCI. We found in patients with chronic SCI that crossed corticospinal fa...
KEY FINDING: Crossed corticospinal facilitation was normal in muscles above the injury in SCI patients.
American Journal of Respiratory and Critical Care Medicine, 2014 • January 1, 2014
This study demonstrates that ventilatory long-term facilitation can be evoked in humans with chronic, incomplete spinal cord injury. Single sessions of intermittent hypoxia induced increases in minute...
KEY FINDING: Minute ventilation significantly increased for 30 minutes after acute exposure to intermittent hypoxia in individuals with chronic spinal cord injury.
PLoS ONE, 2014 • March 20, 2014
The study aimed to quantify different muscle activation patterns in the lower limbs of children with CP using an instrumented assessment. Fifty-four children with CP were included, and their muscle ac...
KEY FINDING: Muscle activation patterns were found to be both muscle- and subject-specific, indicating variability in how spasticity manifests in different muscles and individuals.
Indian Journal of Orthopaedics, 2014 • March 1, 2014
This prospective longitudinal study evaluated body composition changes in 95 patients with acute SCI using DEXA during the first year post-injury. The study found a marked decrease in BMC and LBM with...
KEY FINDING: There was a significant decrease in BMC (P < 0.05) and LBM (P < 0.05) and increase in total body fat mass (TBFM) and percentage fat at infra‑lesional sites.
Translational Psychiatry, 2021 • April 19, 2021
This study investigates the acute effects of therapeutic and overdose concentrations of lithium on human iPSC-derived cortical neurons using MEA and patch-clamp techniques. The findings reveal that th...
KEY FINDING: Therapeutic concentrations of lithium increase neuronal excitability and network activity in human iPSC-derived cortical neurons.