Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 261-270 of 321 results
Respir Physiol Neurobiol, 2019 • July 1, 2019
This review discusses how local circulatory control and oxygen delivery in the spinal cord regulate different pathways to phrenic motor plasticity. Acute intermittent hypoxia (AIH) elicits distinct me...
KEY FINDING: Moderate AIH induces serotonin-dependent pLTF, which is independent of tissue hypoxia and relies on carotid body chemoreceptor activation.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This study compared DXA and MRI for assessing thigh skeletal muscle mass in individuals with spinal cord injury (SCI). The results showed a strong relationship between DXA and MRI measurements, sugges...
KEY FINDING: DXA measurements were strongly correlated with MRI measurements for whole thigh muscle mass, absolute muscle mass (excluding intramuscular fat), and knee extensor muscle mass.
Neurology, 2019 • June 11, 2019
This study assessed the predictive value of midsagittal tissue bridges on MRI for sensorimotor recovery after cervical SCI. The width of dorsal tissue bridges correlated with sensory recovery and SEP ...
KEY FINDING: Greater width of dorsal midsagittal tissue bridges was associated with being sensory incomplete at 12 months, shorter SEP latencies, and greater SEP amplitudes.
PLoS ONE, 2019 • May 24, 2019
This study aimed to quantify urine production during electrical stimulation of the lower urinary tract using different stimulation frequencies in healthy volunteers. The study found that lower urinary...
KEY FINDING: Lower urinary tract electrical stimulation increased urine production per time compared to bladder diary baseline values.
Sensors, 2019 • July 27, 2019
This study characterizes traumatic spinal cord injury (TSCI) neurophysiologically using an intramuscular fine-wire electromyography (EMG) electrode pair. The results from the electrode pair data sugges...
KEY FINDING: The study found asymmetry in muscle activity between the left and right sides of the tail muscles before the injury, suggesting limb dominance.
Frontiers in Cellular Neuroscience, 2019 • August 9, 2019
The current study provides comprehensive investigation of the plasticity, integration, and neuromodulation of electrically evoked sensorimotor inputs in spinal motoneurons, and the resultant motor out...
KEY FINDING: EPSPs and coAPs of the S input exhibited progressive depression.
TEMPERATURE, 2020 • January 1, 2020
Persons with SCI are at higher risk of heat-related illness due to impaired thermoregulatory capacity, caused by a decentralized sympathetic nervous system. Studies show that the degree of thermoregul...
KEY FINDING: Thermoregulatory dysfunction in persons with SCI is proportional to the level of injury, with those with tetraplegia at greatest risk for heat-related illness.
Clin Neurophysiol, 2012 • September 1, 2012
This study investigated the effect of limb segment load on soleus H-reflex amplitude and post activation depression in healthy individuals and one individual with chronic SCI. The results showed that ...
KEY FINDING: Limb segment load decreases post-activation depression of the soleus H-reflex in healthy adults.
Muscle Nerve, 2012 • November 1, 2012
This study investigated the effects of chronic paraplegia on skeletal muscle autophagy in rats. The researchers found that paraplegia led to an upregulation of autophagy markers in the soleus muscle. ...
KEY FINDING: SIRT1 protein expression was reduced by 37% in the paraplegia group compared to the control rats, indicating decreased SIRT1 signaling.
PLoS ONE, 2012 • November 8, 2012
This study explored the impact of the ACTN3 R577X polymorphism on single muscle fiber contractile properties in individuals with spinal cord injury (SCI). The SCI condition provided a standardized env...
KEY FINDING: Absence of a-actinin-3 (XX genotype) resulted in a limitation in the shift of muscle composition towards type IIx fibers and preservation of type I fibers in response to long-term muscle disuse.