Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 281-290 of 321 results
Brain and Behavior, 2021 • January 1, 2021
This review explores the neural basis of the Rubber Hand Illusion (RHI) using neurophysiological techniques like TMS, EP, ERP, and EEG, highlighting their crucial role in understanding RHI. Studies us...
KEY FINDING: TMS studies indicate that motor cortex excitability decreases when the real hand is disembodied during the RHI, and ownership of the rubber hand correlates with normal parietal-motor communication.
Exp Neurol, 2021 • December 1, 2021
This study demonstrates that phrenic motor neurons (PMNs) survive after cervical spinal cord hemisection (C2Hx) in rats, challenging previous findings suggesting substantial motor neuron death caudal ...
KEY FINDING: C2Hx had no detectable impact on phrenic motor neuron survival with either subacute (2-weeks) or chronic (8-weeks) spinal injury.
Journal of Cellular Physiology, 2022 • March 1, 2022
The study investigates the effect of inflammatory stimuli and bile acids on myelin clearance by macrophages. Activation of the LPS-TLR4/NFκB pathway reduces myelin phagocytosis by bone marrow-derived ...
KEY FINDING: Activation of the TLR4-NFκB pathway reduced myelin uptake by bone marrow-derived macrophages (BMDM), while IFNγ-Jak/STAT1 signaling did not.
Frontiers in Cellular Neuroscience, 2021 • November 25, 2021
This study investigates the role of TNF-α in trigeminal neuralgia (TN) by examining its effects on MAPKs phosphorylation and BKCa channels in the trigeminal nucleus caudalis (TNC). The results show th...
KEY FINDING: TNF-α, CCL2, and CXCL1 are significantly increased in the TNC region of ION-CCI rats, suggesting their involvement in trigeminal neuralgia.
Frontiers in Cellular Neuroscience, 2021 • December 15, 2021
This study confirms that a clinical concentration of general anesthetic sevoflurane increased the expression of inflammatory factors in microglia and activated the caspase-3 by upregulating ATPIF1 expr...
KEY FINDING: Sevoflurane upregulates the expression of ATPIF1 to induce inflammation and caspase-3 activation.
Frontiers in Cellular Neuroscience, 2022 • February 7, 2022
This study optimized a method for culturing primary spinal cord neurons, enabling stable cultivation, maturation, and characterization of interneurons isolated from E14 mouse embryos. The cultures wer...
KEY FINDING: Spinal cord interneurons (SpINs) can be cultured long-term (over 2 months) in a defined, simple serum-free medium.
Frontiers in Cellular Neuroscience, 2022 • May 19, 2022
This corrigendum addresses errors found in Figure 5 of the original article concerning ATPIF1's role in sevoflurane-induced microglial inflammatory responses. The errors involved incorrect labeling in ...
KEY FINDING: Correction of identification errors of notes (E–J) in the legend for Figure 5.
bioRxiv, 2023 • February 27, 2023
This study investigates the role of DOCK3 in skeletal muscle using a muscle-specific knockout mouse model. The researchers found that loss of DOCK3 in skeletal muscle leads to impaired muscle regenera...
KEY FINDING: Dock3 mKO mice presented with significant hyperglycemia and increased fat mass, indicating a metabolic role in the maintenance of skeletal muscle health.
Int. J. Mol. Sci., 2023 • March 1, 2023
This study investigates the consequences of axotomy on the function of principal neurons of the primary motor cortex layer V (M1LV) in a rat model of SCI. Transection of the dorsal corticospinal tract...
KEY FINDING: Axotomized M1LV neurons became excessively depolarized after SCI, meaning their resting membrane potential was higher than normal.
J. Pers. Med., 2023 • February 28, 2023
This study evaluated the usefulness of motor potentials evoked transvertebrally at lumbar levels in assessing peroneal nerve regeneration in rats after experimental repair. Recordings were performed 2...
KEY FINDING: MEP and ENG stimulations both resulted in evoked potentials, with larger amplitude values following the application of magnetic pulses.