Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 551-560 of 639 results
Drug Deliv, 2017 • January 1, 2017
The study aimed to improve the clinical utility of dexamethasone acetate (DA) for spinal cord injury (SCI) treatment by enhancing its water solubility, biocompatibility, and reducing side effects thro...
KEY FINDING: DA-loaded polymeric micelles (DA/MPEG-PCL micelles) were successfully prepared with a diameter of approximately 25 nm and sustained DA release in vitro.
Scientific Reports, 2017 • February 7, 2017
This study introduces an aligned nanofibers-hydrogel scaffold as a promising bio-functional platform for nerve injury treatment, providing localized and sustained release of drugs and nucleic acid mol...
KEY FINDING: Aligned axon regeneration was observed as early as one week post-injury, indicating the contact guidance role of the scaffold.
Scientific Reports, 2017 • February 9, 2017
This study investigated the effects of taxol on peripheral nerve regeneration using a rat sciatic nerve transection model. The results indicated that high doses of taxol impair nerve regeneration and ...
KEY FINDING: High-dose taxol (6 mg/kg) significantly impaired neuronal electrophysiological function, as indicated by decreased nerve conductive velocity and increased latency.
Brazilian Journal of Medical and Biological Research, 2017 • January 1, 2017
The study examined the effect of NAC on p-p38 expression and superoxide anion generation (SAG) in the spinal cord of rats with CCI-induced neuropathic pain. CCI led to decreased SFI and increased p-p3...
KEY FINDING: CCI induced a decrease in SFI as well as an increase in p-p38 expression and SAG in the spinal cord.
Malays J Med Sci, 2017 • February 24, 2017
This study aimed to investigate the neuroprotective effects of minocycline on brachial plexus injury in rats using different administration routes (intraperitoneal and intrathecal). The results indica...
KEY FINDING: Motor neuron death and microglial proliferation were observed after traumatic avulsion injury of the ventral nerve root with minocycline administration.
Neural Regeneration Research, 2017 • February 1, 2017
This study investigates the effects of Tanshinone IIA (TIIA) on lower urinary tract (LUT) dysfunction in a rat model of spinal cord injury (SCI). The results indicate that TIIA treatment improves blad...
KEY FINDING: TIIA reduced inflammation and edema in the bladder tissue of SCI rats.
Neural Regeneration Research, 2017 • February 1, 2017
The study demonstrates that edaravone protects spinal cord astrocytes from OGSD/R-induced apoptosis. Edaravone's protective effects are linked to the suppression of the PERK/eIF2α/ATF4 integrated stre...
KEY FINDING: Edaravone significantly suppressed astrocyte apoptosis after oxygen-glucose-serum deprivation/restoration (OGSD/R).
Neural Regeneration Research, 2017 • March 1, 2017
This study aimed to elucidate the mechanisms underlying naringin's ability to enhance remyelination after spinal cord injury (SCI) in rats. The findings revealed that naringin treatment mitigated demy...
KEY FINDING: Naringin treatment significantly reduced myelin sheath loss after spinal cord injury, indicating a protective effect on myelin.
Neural Regeneration Research, 2017 • March 1, 2017
This study investigated the effects of epothilone B (EpoB) on scar formation after spinal cord injury (SCI) in rats. The researchers found that EpoB reduced the number of pericytes and inhibited extra...
KEY FINDING: Epothilone B treatment significantly reduced the protein expression of neuron-glial antigen 2 (NG2) and platelet-derived growth factor receptor β (PDGFRβ), markers associated with pericytes, in the injured spinal cord.
J. Biol. Chem., 2017 • May 19, 2017
The study aimed to generate potent and selective Nanobodies against the ligand-binding domain of the human EphA4 receptor, due to EphA4's role in cell interactions and neurological disorders. Two Nano...
KEY FINDING: Two Nanobodies (Nb 39 and Nb 53) bind EphA4 with nanomolar affinities and are selective for EphA4, with some binding to EphA7.