Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 541-550 of 639 results
Adv Healthc Mater, 2016 • October 1, 2016
This study demonstrates that paclitaxel can be incorporated into electrospun PLA microfibers without modifying their alignment and fiber shape. A local release of paclitaxel from electrospun fibers, i...
KEY FINDING: Paclitaxel can be incorporated into electrospun PLA microfibers without modifying their alignment and fiber shape.
Neural Regeneration Research, 2016 • August 1, 2016
Spinal cord injury (SCI) is a condition without a cure, affecting sensory and/or motor functions. The multiple events activated after SCI require a multi-active drug that could target most of these ev...
KEY FINDING: Tamoxifen has beneficial effects in improving functional locomotor recovery after SCI in various animal models.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2016 • January 1, 2016
This study investigates the potential of combining neural stem cell (NSC) transplantation with erythropoietin (EPO) injections to treat spinal cord injury (SCI) in rats. The findings indicate that NSC...
KEY FINDING: NSCs were observed to survive and migrate within the spinal cord tissue after transplantation, suggesting their viability and potential for integration.
Cells Tissues Organs, 2016 • January 1, 2016
This paper reviews the use of electrospun fibers for drug delivery in spinal cord injury (SCI) treatment, highlighting their potential to guide axonal regeneration and deliver therapeutic drugs locall...
KEY FINDING: Riluzole and NT-3 were successfully incorporated into electrospun PLLA fibers.
Biomaterials, 2017 • January 1, 2017
The study introduces a novel drug delivery system for minocycline (MH) using metal ion-assisted self-assembled complexes within a hydrogel, designed for local intrathecal administration to treat spina...
KEY FINDING: Local delivery of MH at a dose of 1.3 mg/kg generated significantly higher MH concentration in the local spinal cord tissue than intraperitoneal (IP) injection of 495 mg/kg MH over 5 days.
Neural Plasticity, 2016 • September 21, 2016
The study examined the effects of epothilone B, a brain-penetrant microtubule-stabilizing agent (MSA), on cortical and sensory neurons in culture to understand its potential cytotoxic effects in the c...
KEY FINDING: Epothilone B exhibited both axon growth-promoting and growth-inhibiting effects on neurons, depending on its concentration. Picomolar concentrations promoted axon growth in young neurons, while nanosubmicromolar concentrations inhibited growth.
Neural Regeneration Research, 2016 • October 1, 2016
This study investigated the neuroprotective effects of combining methylprednisolone (MP) and rosiglitazone (RSG) after spinal cord injury (SCI) in rats. The results showed that combined treatment with...
KEY FINDING: Combined treatment with methylprednisolone and rosiglitazone significantly suppressed neutrophil infiltration after spinal cord contusion.
Scientific Reports, 2016 • December 6, 2016
This study developed a bFGF-ASC-HP hydrogel for enhanced bFGF delivery to treat spinal cord injuries, combining the benefits of bFGF, ASC, and HP hydrogels. The bFGF-ASC-HP hydrogel was found to signi...
KEY FINDING: The ASC scaffold has a strong affinity for bFGF, enhancing its stability and controlled release.
International Journal of Molecular Sciences, 2016 • December 19, 2016
This study evaluates the toxicity to vertebrates of A6, a potentially useful pesticide derived from α-terthienyl. Exposure of zebrafish larvae to A6 induces larval mortality with marked effects on the ...
KEY FINDING: A6 and cyprodinyl decrease larval survival and affect central neurons at micromolar concentrations.
Future Sci. OA, 2015 • January 1, 2015
Spinal cord regeneration following treatment with a novel membrane-spanning peptide (MSP) expressing the isoleucine-lysine-valine-alanine-valine (IKVAV) epitope was assessed in Balb-c mice. IKVAV-MSP ...
KEY FINDING: IKVAV-MSP group scores increased significantly compared with control groups after 4 weeks of observation (p < 0.05).