Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 561-570 of 639 results
The Journal of Neuroscience, 2017 • July 26, 2017
The mammalian target of rapamycin (mTOR) positively regulates axon growth in the mammalian central nervous system (CNS). Inhibition of S6K1 in CNS neurons promotes neurite outgrowth in vitro by twofol...
KEY FINDING: Inhibition of S6K1 in CNS neurons promotes neurite outgrowth in vitro.
Pharmaceuticals, 2017 • July 5, 2017
This review discusses therapeutic neuro-protective and neuro-regenerative strategies for spinal cord injury (SCI) treatment, focusing on nanofibers as drug delivery systems. It highlights the potential...
KEY FINDING: Nanofiber scaffolds can support graft cells, reconstruct tissue loss, alleviate inflammation, improve axonal regeneration, and act as drug delivery systems in SCI treatment.
BioMed Research International, 2017 • June 12, 2017
This review explores using curcumin to treat spinal cord injuries (SCI) by regulating the mTOR signaling pathway, potentially offering new therapeutic avenues. mTOR signaling is crucial in axon regene...
KEY FINDING: The mTOR signaling pathway plays a vital role in the functional recovery of the central nervous system trauma, especially for axon regeneration and autophagy.
The Journal of Neuroscience, 2017 • August 30, 2017
This study investigates the role of 2-arachidonoylglycerol (2-AG), the major CNS endocannabinoid, in the modulation of chondroitin sulfate proteoglycans (CSPGs) deposition in a progressive model of mu...
KEY FINDING: Inhibition of 2-AG hydrolysis reduces CSPGs accumulation and astrogliosis around demyelinated lesions in the spinal cord of Theiler’s murine encephalomyelitis virus-infected mice.
Neural Regeneration Research, 2017 • June 1, 2017
This study investigates the combined effect of brain injury and tacrolimus on peripheral nerve regeneration in rats with transected sciatic nerves. The results showed that combining brain injury with ...
KEY FINDING: Brain injury or tacrolimus alone, or their combination, alleviated muscle atrophy and nerve fiber impairment while improving sciatic nerve function.
Neural Regeneration Research, 2017 • July 1, 2017
The review focuses on the potential of targeting 14-3-3 adaptor proteins with small molecule drugs to enhance axon outgrowth and regeneration in the central nervous system (CNS). Fusicoccin-A (FC-A), ...
KEY FINDING: Fusicoccin-A (FC-A) stimulates neurite outgrowth from rodent cortical neurons and primary human fetal neurons by stabilizing 14-3-3 protein-protein interactions (PPIs).
JOURNAL OF NEUROTRAUMA, 2018 • February 1, 2018
This study investigates the use of rolipram (Rm)-loaded polymeric micelle nanoparticles (PgP) to reduce secondary injury after spinal cord injury (SCI) in rats. The results demonstrate that PgP can ef...
KEY FINDING: PgP nanoparticles increased rolipram's water solubility by approximately 6.8 times, enabling efficient drug loading.
Frontiers in Pharmacology, 2017 • October 12, 2017
This study presents a novel protocol for obtaining a high yield of oligodendrocyte lineage cells from adult rat meningeal tissue, addressing the need for a readily available source of cells for cell t...
KEY FINDING: A protocol was developed to expand a homogenous culture of 10 millions of meningeal-derived oligodendrocyte lineage cells from 1 cm2 of adult rat spinal cord meninges in approximately 4 weeks.
Frontiers in Pharmacology, 2017 • October 17, 2017
This work demonstrates the effect of combined long-chain omega-3 fatty acids (CFO), EPA and DHA, in nerve regeneration and prevention of NP in mice, shedding light on its mechanism of action. Our resul...
KEY FINDING: CFO at 2.3 g/kg significantly prevented mechanical allodynia and reduced thermal hypernociception in mice compared to animals receiving vehicle only.
Neural Regeneration Research, 2017 • September 1, 2017
This study investigates the therapeutic effects of combining methotrexate (MTX) and methylprednisolone (MP) on spinal cord injury (SCI) in rats. High doses of MP can cause side effects, while MTX has ...
KEY FINDING: The study found that methotrexate (MTX) combined with methylprednisolone (MP) significantly improved motor function in rats with spinal cord injury (SCI). Gait analysis showed improvements in hind limb swing time, stride time, minimum longitudinal deviation, instant speed, footprint area, and regularity index at 4 and 8 weeks post-injury.