Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model

Taxol, a drug used to treat tumors, can have serious side effects, including nerve damage. This study looked at how taxol affects nerve regeneration in rats with a damaged sciatic nerve. The researchers found that high doses of taxol impaired nerve function and reduced nerve connectivity. The expression of nerve growth factors and immunoregulatory factors was also reduced at high doses. These results suggest that taxol can interfere with the local inflammatory environment, hinder nerve regeneration, and slow down recovery from severe peripheral nerve injuries.

• 1
  High-dose taxol (6 mg/kg) significantly impaired neuronal electrophysiological function, as indicated by decreased nerve conductive velocity and increased latency.
• 2
  High-dose taxol altered thermal and mechanical hyperalgesia, reducing sensitivity to cold and mechanical stimulation while decreasing licking latencies in the radiant heat test.
• 3
  Taxol treatment, especially at a high dose, significantly reduced neuronal connectivity, macrophage density, and CGRP expression, indicating impaired nerve regeneration.