Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 481-490 of 639 results
Hereditas, 2023 • April 3, 2023
The study investigates the mechanism by which γ-T3, a form of vitamin E, regulates gastric cancer cells, focusing on its impact on gene expression and signaling pathways. RNA-seq analysis of γ-T3-trea...
KEY FINDING: γ-T3 treatment alters the expression of mRNA and ncRNA in gastric cancer cells, indicating a broad impact on cellular functions.
Toxins, 2023 • March 28, 2023
This study aimed to evaluate the therapeutic potential of Xeomin®, a commercial formulation of botulinum neurotoxin type A (BoNT/A), in a preclinical model of spinal cord injury (SCI) in mice. The res...
KEY FINDING: Xeomin® treatment resulted in significant amelioration of motor deficit in severe SCI mice starting from day 28 compared to saline-treated mice.
Frontiers in Pharmacology, 2023 • July 18, 2023
This study provides a comprehensive analysis of the current research status and frontiers of stem cell therapy for spinal cord injury using bibliometric methods. It identifies key contributors, popula...
KEY FINDING: The study found that research on stem cell therapy for spinal cord injury has been increasing since 2000. Neural Regeneration Research was the journal with the most publications and the fastest cumulative publication growth.
Bioactive Materials, 2023 • April 2, 2023
This review provides a comprehensive overview of microneedle systems, including potential cargos, structural designs, material selection, and drug release mechanisms. The review summarizes different m...
KEY FINDING: Microneedles can easily pass through physical barriers at wound sites and sustainably release drugs, enhancing drug delivery efficiency.
CNS Neuroscience & Therapeutics, 2023 • January 1, 2023
The study aimed to characterize gecko thrombin (gthrombin) due to the rapid coagulation and scarless regeneration observed in geckos after tail amputation, seeking a safe and efficient blood clotting ...
KEY FINDING: Recombinant gthrombin showed super-high catalytic and fibrinogenolytic efficiency compared to human thrombin under various temperature and pH conditions.
Molecules, 2023 • May 11, 2023
This study investigates the neurogenic potential of various semi-synthesized pyranoflavonoids, derived from xanthohumol, using a doublecortin (DCX) promoter-based reporter assay. The research identifie...
KEY FINDING: The chalcone backbone with a pyran ring, as found in xanthohumol C, exhibits the highest neurogenic activity compared to other flavonoid backbones.
Nanoscale Advances, 2023 • May 5, 2023
The study optimized PLGA-based nanoparticles for delivering miRNA-129-5p to modulate activated microglia. Nanoformulations PLGA-miR+Sp and PLGA-miR+PEI showed significant immunomodulatory effects, sus...
KEY FINDING: PLGA-miR+Sp and PLGA-miR+PEI formulations were found to be significant in their immunomodulatory effects compared to naked PLGA-based NPs.
Metabolites, 2023 • August 3, 2023
The study investigates the efficacy of combining a ketogenic diet (KD), metformin (MET), and metronomic cyclophosphamide (CP) as a triple therapy for MYCN-amplified neuroblastoma (NB). Results showed ...
KEY FINDING: MET reduces cell proliferation and mitochondrial respiration in MYCN-amplified NB cell lines.
Asian Journal of Pharmaceutical Sciences, 2023 • August 4, 2023
The study utilized biocompatible mesenchymal stem cell-derived extracellular vesicles as carriers loaded with the CB2 target medicine AM1241 (EVs-AM1241) to protect against neurodegenerative progressi...
KEY FINDING: EVs-AM1241 increased the amount of AM1241 in the brain and improved the biocompatibility of AM1241.
Journal of Neuroimmune Pharmacology, 2023 • September 2, 2023
This study found that aOECs could attenuate inflammatory response by regulating microglia from pro-inflammatory to anti-inflammatory phenotype in SCI rats, thus facilitating functional recovery. The s...
KEY FINDING: CCM-activated OECs effectively attenuated deleterious inflammation by regulating microglia polarization from the pro-inflammatory (M1) to anti-inflammatory (M2) phenotype in SCI rats and facilitated functional recovery after SCI.