Pharmacology Research

KEY FINDING: Alpinetin inhibits microglia-mediated neuroinflammation and the activity of the JAK2/STAT3 pathway, both in vitro and in vivo.

KEY FINDING: The diclofenac sodium-loaded gelatin scaffold significantly reduced the expression of IL-1β and TNF-α, indicating its anti-inflammatory properties.

KEY FINDING: Long-term ethanol exposure has a cytotoxic effect on neuronal cells, inducing apoptosis.

KEY FINDING: Polysaccharide-based DDSs, especially those using chitosan, alginate, and agarose, show promise in treating SCI by promoting axonal regeneration and reducing inflammation.

KEY FINDING: Roflumilast treatment promoted functional recovery in rats with spinal cord injuries, enabling them to support their weight and take occasional steps, as measured by the BBB score.

KEY FINDING: Etizolam (ETZ) administration in the acute phase after spinal cord injury (SCI) reduced the concentration of inflammatory cytokines.

KEY FINDING: Microneedles can improve the delivery of active substances to enhance bioavailability in tissue repair.

KEY FINDING: A wide range of medications (775 unique medications) are administered within the first two months after spinal cord injury.

KEY FINDING: Numerous strategies are being explored to reduce secondary injuries after SCI by targeting mechanisms like excitotoxicity, oxidative stress, inflammation, and cell death.

KEY FINDING: The Gel-Cur-M exhibited superior functions compared to Gel and Cur-M alone, which includes ameliorating hyperalgesia while simultaneously improving locomotor and muscular functions after the nerve injury.