Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 491-500 of 639 results
bioRxiv preprint, 2023 • September 2, 2023
The study developed a customizable hydrogel platform for local delivery of protein therapeutics, using bioorthogonal SPAAC click chemistry for tunable release rates and compatibility with various prot...
KEY FINDING: The release rate of payloads from the hydrogels can be customized by selecting azidoacids of varying lengths, thereby controlling ester hydrophobicity.
Translational Neuroscience, 2023 • August 30, 2023
This study investigates the effects of γ-oryzanol on motor function recovery in mice after spinal cord injury (SCI). The mice were divided into sham, injury, and γ-oryzanol-treated groups, with the γ-...
KEY FINDING: γ-Oryzanol treatment improved gait following SCI, as shown by behavioral tests.
CNS Neuroscience & Therapeutics, 2024 • January 1, 2024
CNS tumors are complex diseases with specific pathogeneses not fully understood and poor prognosis, often resistant to therapies. ncRNAs, including circRNAs, significantly contribute to tumor initiati...
KEY FINDING: CircRNAs participate in multiple molecular mechanisms of cellular normal or pathophysiology processes, especially as miRNA sponges in the cytoplasm, activating the modulation of target genes via miRNA response elements.
Gels, 2023 • November 16, 2023
Natural, synthetic, and composite injectable hydrogels can all be used as delivery systems to encapsulate stem cells, drugs, or GFs for a wide range of applications in SCI therapy. The mechanisms by w...
KEY FINDING: Natural hydrogels are efficient scaffolds for functional recovery and drug/cell delivery after SCI.
The Journal of Neuroscience, 2024 • February 7, 2024
This study investigates the role of HCN ion channels in opioid-induced hyperalgesia (OIH) and opioid-induced tolerance (OIT). The research demonstrates that OIH is driven by HCN2 ion channels in perip...
KEY FINDING: Peripheral HCN2 ion channels drive opioid-induced hyperalgesia (OIH). Blocking or genetically deleting HCN2 in primary nociceptive neurons abolishes OIH.
Nature Communications, 2015 • October 27, 2015
The present work demonstrates that the anti-asthmatic drug and leukotriene receptor antagonist montelukast restores learning and memory function in old rats. Montelukast treatment reduced age-associat...
KEY FINDING: Montelukast treatment significantly improved task learning in old rats to a level comparable to young ones.
Inflammation Research, 2024 • February 11, 2024
This study used Mendelian randomization to investigate the causal effects of lipid-lowering drug targets on psoriatic arthritis (PsA) risk. The analysis revealed a significant association between gene...
KEY FINDING: Genetically proxied PCSK9 inhibition is associated with a decreased risk of psoriatic arthritis (OR: 0.51; 95% CI 0.14–0.88; P < 0.01).
eNeuro, 2024 • February 1, 2024
The study investigated the effect of chronic SSRI treatment on serotonin axon regrowth in mice after a chemical lesion induced by para-chloroamphetamine (PCA). Mice were treated with fluoxetine or ser...
KEY FINDING: Chronic treatment with either fluoxetine or sertraline, two different SSRIs, did not affect the recovery of serotonin axon length in the somatosensory cortex, visual cortex, or hippocampus.
Nanomaterials, 2024 • February 20, 2024
This study successfully synthesized a curcumin-decorated nanozyme (PMC NPs) with significant ROS scavenging and anti-inflammatory properties for neuroprotection. In vitro experiments demonstrated that...
KEY FINDING: PMC NPs exhibit specific SOD-like and CAT-like activities, enabling them to effectively scavenge ROS in physiological conditions.
ACS Pharmacol. Transl. Sci., 2024 • February 7, 2024
This study investigates the role of LIM kinases (LIMKs) in spinal cord injury (SCI) and associated neurodegeneration, focusing on their impact on microtubule dynamics and neuronal regeneration. The fi...
KEY FINDING: Phosphorylated LIMK1 is elevated at chronic time points after SCI, correlating with scar formation and neuronal loss.