Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 461-470 of 639 results
Cell Reports, 2022 • October 25, 2022
The study performs a genome-wide siRNA screen to identify RTN4R as a potent modifier of ataxin-2 levels. RTN4R knockdown or treatment with a peptide inhibitor is sufficient to lower ataxin-2 protein l...
KEY FINDING: Knockdown or peptide inhibition of RTN4R, the gene encoding the RTN4/NoGo-Receptor, lowers ataxin-2 protein levels in mouse and human neurons in vitro.
Frontiers in Neuroscience, 2022 • October 10, 2022
This study investigates the therapeutic effects of astaxanthin (AST) and folic acid (FC) on brachial plexus avulsion (BPA) in rats. The combination of AST and FC showed a synergistic effect due to AST...
KEY FINDING: AST-FC combined therapy effectively alleviated oxidative stress and the inflammatory response in the acute phase of BPA.
Materials Today Bio, 2022 • October 15, 2022
This study focuses on developing a bionic multichannel nanofiber conduit loaded with Tubastatin A (TUBA) to promote spinal cord repair. The conduit is designed to act as a bridge, supporting nerve cell...
KEY FINDING: The Tubastatin A-loaded nanofibers exhibited a sustained-release profile, meaning the drug was released slowly over time, maintaining its activity and promoting axonal extension.
Journal of Nanobiotechnology, 2022 • December 28, 2022
The study developed CaO2@mPDA-SH nanoparticles that can regulate the tumor microenvironment by consuming lactic acid and alleviating hypoxia. The nanoparticles promote immune responses, inhibit angio...
KEY FINDING: CaO2@mPDA-SH nanoparticles can dually regulate tumor hypoxia and lactic acid metabolism.
Advanced Science, 2023 • November 16, 2022
This study identifies cancer cell lines that are sensitive or resistant to OXPHOS inhibition and reveals that the NNMT-DNMT1 axis plays a critical role in determining cancer cell reliance on mitochond...
KEY FINDING: OXPHOS inhibition-sensitive cancer cells exhibit increased OXPHOS activity and silenced NNMT expression.
Inflammation and Regeneration, 2022 • December 1, 2022
This study investigated the effects of Quercetin (QCN) on motor function recovery in a rat model of brachial plexus avulsion (BPA) characterized by spinal ventral root avulsion/reimplantation and illu...
KEY FINDING: QCN significantly expedited motor function recovery in the forelimb, as shown by increased Terzis grooming test scores.
PLOS Neglected Tropical Diseases, 2022 • December 5, 2022
The study analyzed polymorphisms in drug resistance-related genes of P. ovale spp. in samples from travelers returning to China from Africa. High frequencies of S58R and S113N/T mutations were observe...
KEY FINDING: Two podhfr mutations, S58R and S113N/T, were detected in P. ovale curtisi with high/moderate frequencies.
Pharmaceuticals, 2022 • December 19, 2022
This study explored the potential of Andrographolide (Andro) to alleviate post-operative pain in a rat model. The results showed that Andro, when administered via direct injection, significantly reduc...
KEY FINDING: Andro injections significantly reduced mechanical allodynia (pain from a stimulus that doesn't normally cause pain) compared to saline treatment.
iScience, 2023 • January 20, 2023
This study investigates the metabolic mechanisms underlying artemisinin resistance (ART-R) in Plasmodium falciparum, focusing on the role of PfKelch13 mutations and ring-stage growth arrest. The resea...
KEY FINDING: PfKelch13 mutant parasite lines exhibit reduced susceptibility to DHA and prolonged ring stage.
Materials Today Bio, 2023 • January 1, 2023
This review explores the current use of functional nanomaterials for SCI treatment, categorizing them into inorganic, organic, and bioderived NPs based on their source composition. It examines the des...
KEY FINDING: Functional nanomaterials, ranging from 1 to 1000 nm, are categorized into inorganic, organic, and bioderived NPs, each with unique design and structural composition.