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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Pharmacology Research

Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.

Showing 231-240 of 639 results

Spinal Cord InjuryPharmacologyRehabilitation

Development, Content Validity and Reliability of Upper Extremity Functional Skill Measure in C5-C7 Spinal Cord Injury

Cureus, 2023 • April 14, 2023

This study focused on developing and validating the Upper Extremity Functional Skill Measure (UEFSM), a 10-item tool designed to assess hand function in individuals with C5-C7 spinal cord injury (SCI)...

KEY FINDING: The developed UEFSM is a 10-item tool that assesses hand function across four subscales: grasp, grip, pinch, and gross movement.

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PharmacologyNeurologyPain Management

Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain

CNS Neurosci Ther, 2023 • January 1, 2023

This study investigates the role of bile acids and their receptors, TGR5 and FXR, in alleviating neuropathic pain induced by spared nerve injury (SNI) in mice. The results demonstrate that SNI leads t...

KEY FINDING: Bile acid levels are decreased in the spinal dorsal horn after spared nerve injury (SNI), while CYP7A1 expression is upregulated in microglia.

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Spinal Cord InjuryPharmacologyHealthcare

Potentially harmful drug–drug interactions in the therapeutic regimens of persons with spinal cord injury

The Journal of Spinal Cord Medicine, 2024 • March 8, 2023

This study aimed to identify common, potentially harmful drug interactions in individuals with spinal cord injury (SCI) and associated risk factors. The study found that almost three out of ten indivi...

KEY FINDING: Almost three out of ten individuals with spinal cord injury were at risk of having a potentially harmful drug interaction.

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Spinal Cord InjuryPatient ExperiencePharmacology

A scoping review of medication self-management intervention tools to support persons with traumatic spinal cord injury

PLOS ONE, 2023 • April 20, 2023

This scoping review aimed to identify and summarize existing literature on medication self-management interventions for adults with traumatic SCI. The review identified only three relevant studies, hi...

KEY FINDING: There is a lack of literature on medication self-management interventions specifically designed for adults with traumatic SCI.

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PharmacologyPain ManagementResearch Methodology & Design

Long-Term Safety and Efficacy of Mirogabalin for Central Neuropathic Pain: A Multinational, Phase 3, 52-Week, Open-Label Study in Asia

Pain Ther, 2023 • April 28, 2023

This multinational, open-label study assessed the long-term safety and efficacy of mirogabalin for central neuropathic pain (CNeP) in Asian patients with spinal cord injury (CNePSCI), Parkinson's dise...

KEY FINDING: Mirogabalin was generally safe and well-tolerated, with common side effects including somnolence, peripheral edema, edema, and dizziness, most of which were mild.

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Spinal Cord InjuryPharmacologyOrthopedics

Intramuscular Hematomas in Patients Receiving Prophylaxis or Anticoagulant Treatment after Spinal Cord Injury (SCI)—A Rare Complication: Description of Seven Cases and a Literature Analysis

Biomedicines, 2023 • April 10, 2023

This study describes seven cases of spontaneous intramuscular hematomas (SMHs) in patients with spinal cord injuries (SCIs) undergoing rehabilitation. The patients were either receiving anticoagulant ...

KEY FINDING: Intramuscular hematomas are rare complications after SCI, often presenting as sudden limb swelling.

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PharmacologyMental HealthNeurology

Alpha-linolenic acid enhances the facilitation of GABAergic neurotransmission in the BLA and CA1

Experimental Biology and Medicine, 2023 • April 1, 2023

This study demonstrates that ALA increases GABAAR-mediated inhibitory activity in the BLA and CA1 pyramidal neurons 24 h after injection in young adult Sprague-Dawley male rats. The study showed that ...

KEY FINDING: Administration of ALA increased the charge transfer of inhibitory postsynaptic potential currents mediated by GABAA receptors in pyramidal neurons in the BLA and CA1 compared to vehicle animals.

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Spinal Cord InjuryPharmacologyNeurology

Delivery of FGF10 by implantable porous gelatin microspheres for treatment of spinal cord injury

MOLECULAR MEDICINE REPORTS, 2023 • April 25, 2023

Porous GMSs were synthesized using a simple FGF10‑encapsulating procedure. More specifically, GMSs loaded with FGF10 were administered to SCI rats; FGF10 was then slowly released at the site of injury...

KEY FINDING: FGF10-GMS treatment led to superior outcomes in terms of neuroprotection, motor function and morphological recovery compared with FGF10 treatment.

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Spinal Cord InjuryPharmacologyNeurology

Autonomic Dysreflexia: Current Pharmacologic Management

PM R, 2023 • December 1, 2023

This study represents the first assessment of pharmacologic management of AD since the definition was formalized and clinical practice guidelines were published. Most physicians had formalized AD mana...

KEY FINDING: The majority of physicians (69%) had a formal AD management protocol for inpatient care, with nitroglycerin ointment (82%) being the most common first-line medication.

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Spinal Cord InjuryPharmacologyNeurology

Correction: Transient alteration of consciousness in spinal cord injury secondary to Baclofen use: a case report

Spinal Cord Series and Cases, 2023 • January 1, 2023

This document is a correction to a published case report. The correction addresses an error in the description of Baclofen's mechanism of action. The initial publication misidentified Baclofen as a GA...

KEY FINDING: The original article incorrectly stated that Baclofen is a GABA receptor antagonist.

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