Pharmacology Research

KEY FINDING: Laurus nobilis extract-loaded scaffolds reduced tissue expression levels of pro-inflammatory cytokines like TNF-a, IL-1b, and IL-6.

KEY FINDING: The "combo" therapy reduced M1 microglia activation and glutamate levels in the short term, indicating a strong anti-inflammatory effect.

KEY FINDING: A 78-year-old man developed bullous pemphigoid after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine.

KEY FINDING: Dual-EV nanocarriers target human umbilical vascular endothelial cells (HUVECs) and recruit NSCs in vitro.

KEY FINDING: HCPs identified AOM side effects (bowel problems, gastrointestinal distress, skin breakdown, muscle loss) as significant barriers due to potential exacerbation in SCI/D patients.

KEY FINDING: Neurotrophic factors like diencephalon astrocyte derived neurotrophic factor and cerebrolysin can reduce abnormal permeability of the blood-spinal cord barrier and improve functional recovery.

KEY FINDING: Combining EVs with nanoparticles, such as iron oxide nanoparticles (IONP), can improve their targeting ability to the injured spinal cord tissue, especially when guided by an external magnetic field.

KEY FINDING: Smokers had worse improvement in motor score at 1 year compared to nonsmokers (4.61 vs 7.99, P = 0.019).

KEY FINDING: Sarcopenia was associated with a higher prevalence of polypharmacy (OR: 1.65, 95% CI [1.23, 2.20], I2 = 84%, P < 0.01).

KEY FINDING: Electrophysiologically, no treatment provided significant improvement compared to the control group in terms of latency and amplitude.