Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 631-640 of 682 results
The Journal of Neuroscience, 2024 • February 7, 2024
This study investigates the role of HCN ion channels in opioid-induced hyperalgesia (OIH) and opioid-induced tolerance (OIT). The research demonstrates that OIH is driven by HCN2 ion channels in perip...
KEY FINDING: Peripheral HCN2 ion channels drive opioid-induced hyperalgesia (OIH). Blocking or genetically deleting HCN2 in primary nociceptive neurons abolishes OIH.
International Journal of Surgery Case Reports, 2024 • January 2, 2024
This case report describes the successful treatment of a 64-year-old male with a spinal cord injury using percutaneous laser disc decompression (PLDD) combined with umbilical cord-derived mesenchymal ...
KEY FINDING: PLDD significantly reduced the patient's discomfort within 24 hours.
Molecular Pain, 2024 • April 1, 2024
The study analyzed alternative splicing (AS) patterns in mouse brain, dorsal root ganglion (DRG), and spinal cord tissues under inflammatory and neuropathic pain conditions to understand the molecular ...
KEY FINDING: The study identified 6495 differentially alternatively spliced (DAS) genes in the mouse brain, dorsal root ganglion, and spinal cord tissue under inflammatory and neuropathic pain.
Heliyon, 2024 • August 10, 2024
This study investigates the effects and mechanisms of TMS on neuropathic pain after SCI in mice. High-frequency TMS on the primary motor cortex (M1) was performed after SCI, and pain response was eval...
KEY FINDING: TMS significantly improved SCI induced mechanical allodynia, cold and thermal hyperalgesia with a durative effect, and TMS intervention at 1 week after SCI had pain relief advantages than at 2 weeks.
BRAIN, 2025 • September 20, 2024
This study explores the role of LGI1 in regulating pain sensitivity by genetically ablating LGI1 in specific neuron populations of transgenic mice, revealing its high expression in DRG and spinal cord...
KEY FINDING: LGI1 is highly expressed in dorsal root ganglion (DRG) and spinal cord dorsal horn neurons in both mouse and human.
eLife, 2024 • November 15, 2024
This study demonstrates that resident astrocytes, rather than ependymal cells, are the main contributors to neuropathic pain following spinal cord injury (SCI). Selective elimination of resident astro...
KEY FINDING: Resident astrocytes, not ependymal cells, are the primary source of astrocytes that induce neuropathic pain after SCI.
European Journal of Pain, 2025 • January 1, 2025
This translational study examined the interaction between descending inhibitory controls and spinal amplification in pain modulation, using parallel human and rat models. The study found that spinal a...
KEY FINDING: In humans, concurrent application of a noxious conditioning stimulus did not affect pain ratings to a single pinprick stimulus, repetitive stimulation or the wind-up ratio.
Frontiers in Neuroscience, 2025 • January 17, 2025
The study investigates the impact of epidural ULF neuromodulation on thalamic neuron responses to peripheral sensory stimulation and pathological thalamic activity in a neuropathic pain model. Results...
KEY FINDING: ULF current can acutely and reversibly interrupt signaling between sensory afferent fibers and relay neurons of the thalamus.
Bioengineering, 2025 • February 20, 2025
This study compared lumbopelvic kinematics in individuals with and without low back pain (LBP) before and after fatigue. Repetitive lifting induced fatigue, significantly affecting lumbopelvic kinemat...
KEY FINDING: Fatigue significantly altered lumbopelvic kinematics, specifically anterior/posterior translation and rotation around the z-axis, in both groups.
Front. Neuroanat., 2015 • April 10, 2015
This study investigates the impact of pelvic and hypogastric nerve injuries on the central terminals of sensory axons in the sacral and upper lumbar spinal cord of rats. The researchers examined chang...
KEY FINDING: Pelvic nerve injury increased GFRα1-immunoreactivity (IR) in the medial dorsal horn of the sacral spinal cord.