Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 641-650 of 682 results
Exp Neurol, 2015 • September 1, 2015
This study investigated the effects of artemin, NGF, and GDNF on sensory axon regeneration following dorsal root injury in rats, focusing on the extent and topographic targeting of regenerating axon s...
KEY FINDING: Artemin, when expressed in the spinal cord, selectively induced regeneration of CGRP+ axons (related to pain sensation) and promoted their topographic targeting within the superficial dorsal horn.
Cell Transplantation, 2017 • March 23, 2017
The study examines the impact of OEC/ONF transplants on forepaw thermal responses following dorsal root avulsion in rats, finding that transplants prevented heightened sensitivity to heat and cold. Hi...
KEY FINDING: Dorsal root avulsion in rats leads to a transient period of exaggerated responses to heat and cold stimuli on the forepaw.
Neural Regeneration Research, 2015 • October 1, 2015
This study investigates the expression profiles of aminoacyl-tRNA synthetases (AminoARSs) in the spinal cord dorsal horn following peripheral nerve injury in rats. The results demonstrate that the mRN...
KEY FINDING: Following sciatic nerve axotomy in rats, the mRNA expression of FARSB, IARS, and MARS significantly increased in the injured L4–5 spinal cord compared to control regions.
PLoS ONE, 2016 • April 6, 2016
This study identifies and characterizes two potent and selective arylsulfonamide Nav1.7 inhibitors, PF-05198007 and PF-05089771, to investigate Nav1.7's role in nociceptor physiology. The findings dem...
KEY FINDING: Nav1.7 is the predominant functional TTX-sensitive Nav in mouse and human nociceptors, contributing to the initiation and upstroke phase of the nociceptor action potential.
PLoS ONE, 2016 • July 21, 2016
This study investigates the potential of human amniotic fluid-derived mesenchymal stem cells (hAFMSCs) to alleviate neuropathic pain in a rat model of chronic constriction injury (CCI). The results de...
KEY FINDING: hAFMSCs attenuated the expression IL-1β, TNF-α and synaptophysin in dorsal root ganglion cell culture.
The Journal of Neuroscience, 2016 • November 16, 2016
This study examined the synaptic integration of transplanted medial ganglionic eminence (MGE) cells into the adult spinal cord. The researchers found that MGE cells integrate into host circuitry, deve...
KEY FINDING: MGE cells transplanted into the spinal cord, whether before or after nerve injury, develop into mature neurons with firing patterns characteristic of inhibitory interneurons.
Redox Biology, 2017 • January 1, 2017
This study investigates the role of PKG1 in neuropathic pain and nerve regeneration. The research demonstrates that PKG1 deficiency impairs nerve regeneration, leading to increased neuropathic hyperal...
KEY FINDING: PKG1 deficiency in peripheral neurons exacerbates neuropathic pain and impairs nerve regeneration after injury.
Neural Regeneration Research, 2016 • December 1, 2016
This study examines the impact of "Three Methods and Three Points" tuina therapy on rats with sciatic nerve injuries, focusing on pain reduction, muscle recovery, and nerve regeneration. The findings ...
KEY FINDING: Tuina treatment improved paw withdrawal latency, indicating reduced pain sensitivity in the treated rats.
Brazilian Journal of Medical and Biological Research, 2017 • January 1, 2017
The study examined the effect of NAC on p-p38 expression and superoxide anion generation (SAG) in the spinal cord of rats with CCI-induced neuropathic pain. CCI led to decreased SFI and increased p-p3...
KEY FINDING: CCI induced a decrease in SFI as well as an increase in p-p38 expression and SAG in the spinal cord.
Molecular Pain, 2017 • January 1, 2017
The study investigates the role of Shank2 protein in NMDA-induced pain hypersensitivity in mice, focusing on the spinal cord mechanisms involved. It demonstrates that Shank2 knockout mice exhibit redu...
KEY FINDING: Intrathecal NMDA injection evoked spontaneous nociceptive behaviors, which were significantly reduced in Shank2 KO mice, suggesting that the spinal Shank2 protein is involved in NMDA-induced pain transmission.