Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 201-210 of 682 results
Int. J. Mol. Sci., 2024 • June 29, 2024
The study investigated the effects of intramuscular pulsed radiofrequency (PRF) on complicated pain using a two-stage animal study. The first stage examined the effects of PRF on muscle and sciatic ne...
KEY FINDING: PRF upregulates brain-derived neurotrophic factor (BDNF) in the spinal cord in both groups of rats.
Frontiers in Neuroscience, 2021 • March 22, 2021
This study investigates the effects of combining environmental enrichment (EE) and ketamine on neuropathic pain and motor dysfunction in rats with spinal cord injury (SCI). The results demonstrate tha...
KEY FINDING: The joint treatment of EE and ketamine provided greater relief of pain-like behaviors and locomotor recovery than either paradigm alone.
Pain Research and Management, 2022 • July 8, 2022
This study explored the relationship between pain, bone metastasis, and cytokine expression in cancer patients treated with external radiation therapy. The research aimed to identify specific cytokine...
KEY FINDING: Radiotherapy significantly improved pain scores and quality of life in cancer patients with bone metastasis.
Journal of Traditional Chinese Medicine, 2023 • December 14, 2022
This study aimed to investigate the analgesic effects of Chinese Tuina on neuropathic pain in rats by examining synaptic structure remodeling in the spinal cord dorsal horn (SCDH). The results showed ...
KEY FINDING: Tuina and MK-801 (an NR2B antagonist) reversed CCI-induced changes in motor function and reduced mechanical and cold allodynia in rats.
The Journal of Spinal Cord Medicine, 2023 • July 1, 2023
This study investigated the misuse of gabapentinoids in patients with neuropathic pain related to spinal cord injury, finding a high prevalence of misuse, particularly with pregabalin. The study ident...
KEY FINDING: The misuse rate was 81.9% in patients using pregabalin and 69.69% in patients using gabapentin.
The Journal of Spinal Cord Medicine, 2024 • January 1, 2024
This study evaluated the perceived helpfulness of various treatments for neuropathic pain (NeuP) following spinal cord injury (SCI). The research involved a multicenter cross-sectional survey of 391 i...
KEY FINDING: Non-tramadol opioids, cannabinoids, and anti-epileptics were the pharmacological treatments most often rated as helpful for neuropathic pain.
The Journal of Spinal Cord Medicine, 2024 • September 8, 2022
The mechanisms of the predictive effects of pain severity on school/work functioning in youth with SCI are explained in part by the serial multiple mediator effects of pain interference and social fun...
KEY FINDING: Pain predictive effects on school/work functioning were serially mediated by pain interference and social functioning.
Neural Regeneration Research, 2023 • November 25, 2022
The study investigated the effects of exercise combined with adipose-derived stem cells (ADSCs) on neuropathic pain after spinal cord injury (SCI) in a mouse model. The results demonstrated that the c...
KEY FINDING: Exercise combined with ADSC administration partially improved early motor function recovery after SCI.
CNS Neurosci Ther, 2023 • January 1, 2023
This study investigates the role of bile acids and their receptors, TGR5 and FXR, in alleviating neuropathic pain induced by spared nerve injury (SNI) in mice. The results demonstrate that SNI leads t...
KEY FINDING: Bile acid levels are decreased in the spinal dorsal horn after spared nerve injury (SNI), while CYP7A1 expression is upregulated in microglia.
Mediators of Inflammation, 2023 • April 10, 2023
This study investigated the effects of AdipoRon on neuropathic pain (NeuP) in mice, focusing on its impact on microglia and the AdipoR1/AMPK pathway. The results showed that AdipoRon alleviated mechan...
KEY FINDING: AdipoRon alleviated mechanical nociception in spared nerve injury (SNI) mice, indicating a reduction in pain sensitivity.