Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 191-200 of 682 results
Journal of Pain Research, 2024 • June 10, 2024
This case series evaluated the effectiveness of burst and high-frequency spinal cord stimulation (SCS) in eight patients with central neuropathic pain (CNP) following spinal cord injury (SCI). The stu...
KEY FINDING: Only two out of eight patients experienced significant pain relief with spinal cord stimulation (SCS) over a one-year follow-up.
Brain Sci., 2024 • June 9, 2024
Neuropathic pain involves complex interactions of biological, social, and psychological factors, characterized by amplified nociceptive signaling in the PNS and CNS. Neuromodulation offers potential t...
KEY FINDING: Neuromodulation therapies in the DRG and spinal cord decrease hyperalgesic cytokine production, including TNF-α, IL-1β, IL-6, and HMGB1.
Medicina, 2024 • June 17, 2024
This study investigated the roles of CBP and MeCP2 in neuropathic pain using a spared nerve injury (SNI) rat model. The researchers measured the expression levels of these proteins in the spinal cord ...
KEY FINDING: SNI induced a significant increase in the number of CBPs in the L4 dorsal horn of the spinal cord compared to control groups, indicating an upregulation of CBP expression after nerve injury.
Pharmaceuticals, 2024 • June 16, 2024
The study aimed to investigate the anti-inflammatory and analgesic effects of daphnetin (DAP) and explore the underlying mechanisms of action in neuropathic pain (NP). DAP treatment ameliorated the MW...
KEY FINDING: DAP treatment ameliorated the mechanical withdrawal threshold (MWT) and thermal withdrawal threshold (TWT) in CCI rats, indicating reduced pain sensitivity.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This study investigated the prevalence and predictors of publicly funded prescription opioid use among individuals with traumatic spinal cord injury (TSCI) in Ontario, Canada. The study found that ove...
KEY FINDING: Over half (55%) of individuals with TSCI who are eligible for Ontario's public drug program used opioids in the year following their injury.
Cureus, 2020 • September 21, 2020
Telerehabilitation (telerehab) has emerged as a crucial method for providing physical therapy during the COVID-19 pandemic. It uses technology to deliver care remotely, particularly benefiting spine p...
KEY FINDING: Telerehab can reduce pain and improve physical function in patients with chronic musculoskeletal pain from low back pain, lumbar stenosis, neck pain, and osteoarthritis.
Journal of Molecular Neuroscience, 2024 • October 17, 2024
This study examined the effects of different electroacupuncture (EA) frequencies (2 Hz, 100 Hz, and 18 kHz) on neuropathic pain in mice with sciatic nerve damage. Analgesic effects were evaluated by m...
KEY FINDING: The analgesic effect of EA on neuropathic pain in mice was frequency-dependent.
Molecular Pain, 2024 • January 1, 2024
This study investigates the therapeutic effects of Kilohertz High Frequency Electrical Stimulation (KHES) on neuropathic pain in mice, focusing on the TRPV1/NMDAR2B signaling pathway. The results demo...
KEY FINDING: KHES significantly alleviated mechanical and thermal allodynia in neuropathic pain mice, demonstrating its potential as a treatment.
PLoS ONE, 2023 • May 2, 2023
This cross-sectional prospective study will explore the previously understudied hypothesis that SRBDs are associated with increased neuropathic pain, spasticity, and cardiovascular autonomic dysfuncti...
KEY FINDING: Individuals with SCI and untreated SRBDs will develop more intense neuropathic pain.
Frontiers in Public Health, 2024 • June 19, 2024
This study quantitatively assessed the utility of the SeePain, an educational resource for individuals with spinal cord injury (SCI) experiencing chronic pain. The resource addresses clarity/comprehen...
KEY FINDING: Participants reported high levels of agreement with the overall comprehensibility and clarity of the SeePain resource, finding the language understandable and the figures and tables clear.