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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Oncology Research

Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.

Showing 31-40 of 200 results

Spinal Cord InjuryOncologyResearch Methodology & Design

Efficacy and toxicity of primary re-irradiation for malignant spinal cord compression based on radiobiological modelling: a phase II clinical trial

British Journal of Cancer, 2023 • December 8, 2022

This phase II clinical trial evaluated the efficacy and toxicity of primary re-irradiation for malignant spinal cord compression (MSCC) using a biologically effective dose-based approach. The study fo...

KEY FINDING: Re-irradiation is an effective treatment for MSCC, with 81.8% of evaluable patients experiencing stable or improved mobility at 5 weeks post-treatment.

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OncologyGenetics

Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression

Frontiers in Cell and Developmental Biology, 2022 • December 23, 2022

Non-coding RNAs (ncRNAs) play a crucial role in various cellular processes, and their deregulation is associated with retinoblastoma (RB) progression. Several ncRNAs act as tumor suppressors or promot...

KEY FINDING: miR-491-3p acts as a tumor suppressor gene in RB, inhibiting the growth and metastasis of tumors by targeting SNN.

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Sleep MedicineOncology

Improvement of sleep quality in isolated metastatic patients with spinal cord compression after surgery

World Journal of Surgical Oncology, 2023 • January 11, 2023

This study aimed to evaluate changes in sleep quality (QoS) in isolated metastatic patients with spinal cord compression following surgical treatments (TES and PSRS) and to identify factors contributi...

KEY FINDING: Patients with spinal cord compression caused by metastatic disease experienced significantly improved sleep quality after undergoing TES and PSRS treatments.

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Spinal Cord InjuryOncology

Preoperative Embolization of Metastatic Spinal Cord Compression With N-Butyl Cyanoacrylate: Safety and Effectiveness in Limiting Blood Loss

J Vasc Interv Radiol, 2023 • April 1, 2023

This retrospective study evaluated the safety and efficacy of preoperative embolization using n-BCA for patients with metastatic spinal cord compression. Only one patient experienced severe adverse ev...

KEY FINDING: Preoperative embolization with n-BCA is a safe procedure for MSCC.

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Oncology

Risk of Myelopathy Following Second Local Treatment after Initial Irradiation of Spine Metastasis

Diagnostics, 2023 • January 4, 2023

This review highlights important issues for the reirradiation of patients with vertebral metastases, including the median time to reirradiation of 14 months. The use of highly conformal techniques in ...

KEY FINDING: For 3D radiotherapy, cumulative doses from 55.2 Gy2/2 to 65.5 Gy2/2 EQD2 showed no cases of radiation-induced myelopathy.

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Spinal Cord InjuryOncologyImmunology

Immune response following traumatic spinal cord injury: Pathophysiology and therapies

Frontiers in Immunology, 2023 • January 6, 2023

Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with significant loss of function and/or permanent disability. The pathophysiology of SCI is complex and occurs in...

KEY FINDING: Following tSCI, the immune response likely exerts both beneficial and harmful roles and as previously discussed both the innate and adaptive immune systems have been implicated in secondary injury progression in tSCI.

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OncologyMedical ImagingBioinformatics

Fully automated clinical target volume segmentation for glioblastoma radiotherapy using a deep convolutional neural network

Pol J Radiol, 2023 • January 19, 2023

This study evaluated a deep convolutional neural network (CNN) model for the automatic segmentation of the clinical target volume (CTV) in glioblastoma patients, aiming to improve the efficiency and c...

KEY FINDING: The proposed model achieved high segmentation accuracy with a Dice Similarity Coefficient (DSC) of 89.60 ± 3.56% and a Hausdorff distance of 1.49 ± 0.65 mm.

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OncologyMedical ImagingResearch Methodology & Design

Carotid body paraganglioma metastatic to spine causing cord compression: a case report

Diagnostic Pathology, 2023 • February 10, 2023

This case report describes a rare presentation of carotid body paraganglioma (CBT) with distant metastasis to the thoracic spine, resulting in spinal cord compression in a 40-year-old female. The pati...

KEY FINDING: Carotid body tumors, while typically benign, can exhibit metastatic potential, even many years after initial diagnosis and treatment.

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OncologySurgery

A less aggressive approach to the treatment of aggressive vertebral hemangioma of the thoracic spine: A case report and literature review

International Journal of Surgery Case Reports, 2023 • March 22, 2023

Aggressive vertebral hemangiomas (AVH) are rare tumors that can cause pain and neurological problems. Treatment options vary, but there's no consensus on the best approach. This case report describes ...

KEY FINDING: Less aggressive treatments for AVH, such as embolization and decompression with vertebroplasty, can be effective.

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Spinal Cord InjuryOncologyImmunology

An emerging role of inflammasomes in spinal cord injury and spinal cord tumor

Frontiers in Immunology, 2023 • March 9, 2023

This review highlights the emerging role of inflammasomes in spinal cord injury (SCI) and spinal cord tumors, emphasizing their involvement in neuroinflammation and immune responses. Inflammasomes, intr...

KEY FINDING: SCI leads to primary physical injury followed by secondary injury caused by inflammation, ischemia, oxidative stress, axonal degeneration and glial scar formation.

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