Browse the latest research summaries in the field of oncology for spinal cord injury patients and caregivers.
Showing 31-40 of 200 results
British Journal of Cancer, 2023 • December 8, 2022
This phase II clinical trial evaluated the efficacy and toxicity of primary re-irradiation for malignant spinal cord compression (MSCC) using a biologically effective dose-based approach. The study fo...
KEY FINDING: Re-irradiation is an effective treatment for MSCC, with 81.8% of evaluable patients experiencing stable or improved mobility at 5 weeks post-treatment.
Frontiers in Cell and Developmental Biology, 2022 • December 23, 2022
Non-coding RNAs (ncRNAs) play a crucial role in various cellular processes, and their deregulation is associated with retinoblastoma (RB) progression. Several ncRNAs act as tumor suppressors or promot...
KEY FINDING: miR-491-3p acts as a tumor suppressor gene in RB, inhibiting the growth and metastasis of tumors by targeting SNN.
World Journal of Surgical Oncology, 2023 • January 11, 2023
This study aimed to evaluate changes in sleep quality (QoS) in isolated metastatic patients with spinal cord compression following surgical treatments (TES and PSRS) and to identify factors contributi...
KEY FINDING: Patients with spinal cord compression caused by metastatic disease experienced significantly improved sleep quality after undergoing TES and PSRS treatments.
J Vasc Interv Radiol, 2023 • April 1, 2023
This retrospective study evaluated the safety and efficacy of preoperative embolization using n-BCA for patients with metastatic spinal cord compression. Only one patient experienced severe adverse ev...
KEY FINDING: Preoperative embolization with n-BCA is a safe procedure for MSCC.
Diagnostics, 2023 • January 4, 2023
This review highlights important issues for the reirradiation of patients with vertebral metastases, including the median time to reirradiation of 14 months. The use of highly conformal techniques in ...
KEY FINDING: For 3D radiotherapy, cumulative doses from 55.2 Gy2/2 to 65.5 Gy2/2 EQD2 showed no cases of radiation-induced myelopathy.
Frontiers in Immunology, 2023 • January 6, 2023
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with significant loss of function and/or permanent disability. The pathophysiology of SCI is complex and occurs in...
KEY FINDING: Following tSCI, the immune response likely exerts both beneficial and harmful roles and as previously discussed both the innate and adaptive immune systems have been implicated in secondary injury progression in tSCI.
Pol J Radiol, 2023 • January 19, 2023
This study evaluated a deep convolutional neural network (CNN) model for the automatic segmentation of the clinical target volume (CTV) in glioblastoma patients, aiming to improve the efficiency and c...
KEY FINDING: The proposed model achieved high segmentation accuracy with a Dice Similarity Coefficient (DSC) of 89.60 ± 3.56% and a Hausdorff distance of 1.49 ± 0.65 mm.
Diagnostic Pathology, 2023 • February 10, 2023
This case report describes a rare presentation of carotid body paraganglioma (CBT) with distant metastasis to the thoracic spine, resulting in spinal cord compression in a 40-year-old female. The pati...
KEY FINDING: Carotid body tumors, while typically benign, can exhibit metastatic potential, even many years after initial diagnosis and treatment.
International Journal of Surgery Case Reports, 2023 • March 22, 2023
Aggressive vertebral hemangiomas (AVH) are rare tumors that can cause pain and neurological problems. Treatment options vary, but there's no consensus on the best approach. This case report describes ...
KEY FINDING: Less aggressive treatments for AVH, such as embolization and decompression with vertebroplasty, can be effective.
Frontiers in Immunology, 2023 • March 9, 2023
This review highlights the emerging role of inflammasomes in spinal cord injury (SCI) and spinal cord tumors, emphasizing their involvement in neuroinflammation and immune responses. Inflammasomes, intr...
KEY FINDING: SCI leads to primary physical injury followed by secondary injury caused by inflammation, ischemia, oxidative stress, axonal degeneration and glial scar formation.