Incidence of skeletal-related events in patients with Ewing sarcoma: An observational retrospective study in Japan

This study looks at skeletal-related events (SREs) in patients with Ewing sarcoma, a rare bone cancer. SREs include fractures, surgery, radiation to bones, spinal cord compression, and high calcium levels. The researchers reviewed data from 146 patients treated for Ewing sarcoma between 2005 and 2019 to determine how often SREs occur and what factors might increase the risk. The study found that SREs are not rare in Ewing sarcoma patients, with spinal cord compression being a particularly common issue. Patients with metastasis, especially in bone or bone marrow, or those with recurrence after treatment, require careful monitoring.

• 1
  SREs occurred in 23 patients during the study period, with radiation to the bone and malignant spinal cord compression being the most frequent initial events.
• 2
  The SRE-free rate was approximately 94%, 87%, and 80% at 1, 2, and 3 years after the initial visit, respectively.
• 3
  Bone metastasis at diagnosis, bone marrow invasion, and local progression or recurrence after definitive treatment were identified as independent risk factors for SREs.