Immunology Research

KEY FINDING: The combined therapy resulted in a reduced glial response and a 70% improvement in behavioral motor recovery.

KEY FINDING: CD22 is expressed in B cells, neutrophils, monocytes, and microglia-derived exosomes in human peripheral blood from NMOSD patients and controls, as well as in a mouse model of NMOSD.

KEY FINDING: IL-3 expression was significantly upregulated post-SCI, peaking at 14 days post-injury (dpi) and persisting until 28 dpi. Notably, IL-3 was primarily secreted by astrocytes surrounding the lesion epicenter.

KEY FINDING: Foam cells formed after myelin debris internalization were predominantly macrophages rather than microglia after spinal cord injury.

KEY FINDING: BLT1-knockout mice exhibited a 23 % decrease in neutrophils and 10 % decrease in macrophages after SCI compared to the wild-type mice.

KEY FINDING: NMVs exhibit an "efferocytosis-like" effect, being endocytosed by macrophages and reprogramming them to a pro-regenerative phenotype by influencing glutamine metabolism and oxidative phosphorylation.

KEY FINDING: Ectopic expression of allogeneic MHC in the recipient thymus leads to stable expression in TECs and DCs.

KEY FINDING: A novel subcluster of microglia exhibiting M1 polarization and a ferroptosis phenotype is involved in SCI, potentially triggering neuroinflammation and neuronal degeneration.

KEY FINDING: Three distinct macrophage subtypes were identified in the injured spinal cord: border-associated macrophages (BAMs), inflammatory macrophages (IMs), and chemotaxis-inducing macrophages (CIMs).

KEY FINDING: The Lightgel/NGF/CeMn NP-PEG composite effectively eliminates ROS, promoting M2 macrophage polarization. It also reduces pro-inflammatory cytokines, and supports neuronal regeneration in SCI rats.