Immunology Research

KEY FINDING: PfKelch13 mutant parasite lines exhibit reduced susceptibility to DHA and prolonged ring stage.

KEY FINDING: Tocilizumab treatment significantly increased the expression of claudin-5 (CLDN5) and zonula occludens-1 (ZO-1) between vascular endothelial cells at 14 and 28 days post-injury.

KEY FINDING: The prevalence of smell and taste alterations did not significantly decrease during the Omicron dominance compared to earlier phases of the pandemic.

KEY FINDING: Astrocytes, while not part of the immune system, play essential roles in the immune response to SCI by recruiting immune cells and secreting immunomodulatory molecules. Reactive astrocytes can be either protective or detrimental.

KEY FINDING: Hypoimmunogenic hPSCs, regardless of HLA molecule expression patterns, maintain normal self-renewal capacity.

KEY FINDING: Platelet depletion in APP-PS1 female mice shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus.

KEY FINDING: B2m, Itgb5, and Vav1 were identified as key immune genes in macrophages/microglia during the subacute phase of SCI.

KEY FINDING: Tau inhibition after spinal cord injury down-regulated the levels of inflammatory mediators, including tumor necrosis factor-α, interleukin-6 and interleukin-1β.

KEY FINDING: Loss of IFITM1 promotes brain colonization of human lung cancer cells, identified through in vivo genome-wide CRISPR-Cas9 screening.

KEY FINDING: MSCs can suppress immunity against inflammation by direct contact with immune cells or paracrine activity, modulating the release of cytokines and growth factors at the injury site.