Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 421-430 of 730 results
JOURNAL OF NEUROTRAUMA, 2018 • November 1, 2018
The study investigated the relationship between plasma GFAPab, CRMP2ab, and neuropathic pain in SCI patients. The presence of plasma GFAPab in the chronic stage of injury does not differentiate betwee...
KEY FINDING: Plasma GFAPab in the chronic stage of SCI does not correlate with neuropathic pain.
Brain, 2018 • May 30, 2018
The study investigated whether inducing mild neuroinflammation could enhance the effectiveness of rehabilitative training in rats with chronic spinal cord injury. Rats with chronic cervical spinal cor...
KEY FINDING: Systemic injection of a low dose of lipopolysaccharide improved the efficacy of rehabilitative training on forelimb function, as assessed using a single pellet reaching and grasping task.
BMJ Case Rep, 2018 • May 30, 2018
This is a rare case of Varicella zoster virus (VZV) lumbosacral plexopathy in an 84-year-old women presenting with lower limb weakness and rash. After a prolonged course of oral acyclovir and inpatien...
KEY FINDING: Contrast-enhanced MRI revealed enhancement of the left L3–L5 descending nerves and left lumbosacral plexus, indicative of inflammatory/infectious aetiology.
Spinal Cord Series and Cases, 2018 • May 13, 2018
This study evaluated the acute effects of concentrated proanthocyanidins (PACs) on bacteriuria, leukocyturia, and subjective urine quality in catheter-dependent veterans with SCI. The results showed n...
KEY FINDING: There was no significant decrease in colony forming units per milliliter (cfu/ml) in the treatment vs. the control group.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This study evaluated the impact of long-term nitrofurantoin for UTI prophylaxis in veterans with SCI. Long-term prescription of nitrofurantoin may reduce UTIs in veterans with SCI and there is no evid...
KEY FINDING: UTIs were less frequent in cases receiving long-term nitrofurantoin compared to controls.
JOURNAL OF NEUROTRAUMA, 2019 • March 15, 2019
This study investigates the role of bone marrow-derived monocytes in the inflammatory microenvironment after thoracic spinal cord injury (SCI). The research focuses on the infiltration of peripheral m...
KEY FINDING: Macrophages are recruited to both the epicenter and lumbar cord after thoracic SCI, and they persist for at least seven days.
Neural Regeneration Research, 2018 • September 1, 2018
This mini-review discusses two recent studies that used functional genomics to investigate gene expression in circulating leukocytes isolated from persons with SCI to identify therapeutic strategies t...
KEY FINDING: Individuals with SCI levels rostral to T5, where sympathetic nervous system disruption would occur, had more differentially expressed genes (N = 2226) compared to able-bodied participants.
Journal of Neuroinflammation, 2018 • September 6, 2018
This study investigated the role of macrophage migration inhibitory factor (MIF) in the production of chemokine (C-C motif) ligand 5 (CCL5) in astrocytes following rat spinal cord injury. The results ...
KEY FINDING: CCL5 protein levels were increased in astrocytes of rat injured spinal cord, in parallel with the expression of MIF.
ENEURO, 2018 • August 13, 2018
This study establishes L-selectin as a determinant of long-term recovery and tissue sparing after spinal cord injury (SCI). The research demonstrates that L-selectin contributes to secondary pathogene...
KEY FINDING: L-selectin knockout (KO) mice showed improved long-term recovery with greater white matter sparing relative to wild-type (WT) mice and reduced oxidative stress in the injured cord at 72 h post-SCI.
Spinal Cord Series and Cases, 2018 • August 1, 2018
This case report describes changes in urine inflammatory biomarkers and the urine microbiome over an 8-month period in a patient with NB with augmentation cystoplasty secondary to SCI. The finding of po...
KEY FINDING: Burkholderia fungorum was present in three samples during both asymptomatic and symptomatic periods, identified by 16S rRNA sequencing but not by traditional cultivation methods.