Immunology Research

KEY FINDING: C3−/− mice demonstrated a 2-fold increase in sensory axon regeneration in the spinal cord compared to wildtype C3+/+ mice 6 weeks after dorsal hemisection with peripheral conditioning lesion.

KEY FINDING: Most positive urine cultures from SCI annual evaluations represented ASB cases.

KEY FINDING: Low-intensity treadmill exercise improved neuropathic pain behaviors in mice, including mechanical hyperalgesia, escape/avoidance behavior, and spontaneous locomotor activity.

KEY FINDING: Transplanted MSCs migrate to the injury site but do not turn into nerve or glial cells.

KEY FINDING: People with SCI showed lower proportions of naïve T-cells and more memory T-cells compared to age-matched controls, indicating a shift towards an older immune profile.

KEY FINDING: There is a marked downregulation of natural killer cell genes in individuals with chronic SCI.

KEY FINDING: Chronic inflammation worsens secondary medical complications and amplifies the risk for cardiometabolic disorders after injury, directly impacting both the quality of life and mortality risk after SCI.

KEY FINDING: The interrater reliability of combined leukocyte esterase and nitrite urine dipstick test was moderate agreement.

KEY FINDING: Adjunctive homeopathic treatment led to a significant decrease in the number of self-reported UTI in the homeopathy group, whereas it remained unchanged in the control group.

KEY FINDING: Patients with UTIs had significantly lower FIM motor scores on admission, discharge, and gain compared to those without a UTI.