Immunology Research

KEY FINDING: BUB C1q KO mice exhibited greater locomotor recovery compared with BUB WT mice.

KEY FINDING: OECs exhibit innate immune function, secrete immunoregulatory molecules, and possess phagocytic activity, maintaining microenvironmental homeostasis to support neuronal survival and outgrowth.

KEY FINDING: NOD-SCID mice exhibited the greatest locomotor recovery in the open field compared to C57BL/6 and BUB/BnJ mice.

KEY FINDING: Significant improvements in forelimb function were observed one week post-injury in the group treated with PEGylated IFN-β, but these improvements were not sustained long-term.

KEY FINDING: Mice deficient in factor B (fB), a protein in the alternative complement pathway, were protected from traumatic SCI, showing reduced tissue damage, demyelination, and inflammatory cell infiltrate.

KEY FINDING: Substantial differences exist among SCI centers in the indications for UTI treatment, medications used, and treatment duration, often deviating from existing guidelines.

KEY FINDING: Conditioned media from polymorphonuclear leukocytes (PMN) selectively increased hNSC astrogliogenesis and promoted cell migration in vitro.

KEY FINDING: Inpatient culture, male gender, sputum and other specimen type, receipt of antibiotics within 90 days before culture date, and pressure ulcers were identified as independent predictors of MDR Acinetobacter.

KEY FINDING: Obesity in SCI leads to chronic inflammation due to proinflammatory adipokines released from excess adipose tissue.

KEY FINDING: Foul smelling urine had the highest sensitivity (0.50, 95% CI: 0.31-0.69) for UTI diagnosis.