Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 341-350 of 730 results
Brain, Behavior, & Immunity - Health, 2020 • July 25, 2020
This study investigated the impact of nerve injury on mood disorders and memory loss, examining the roles of cytokines, growth factors, and glial cells in the process. The researchers induced nerve in...
KEY FINDING: Nerve injury induces depressive-like and anxiety-like behaviors as well as impairment in short-term memory in mice.
Journal of Neuroinflammation, 2022 • January 1, 2022
In summary, multiple hypotheses have been proposed for the pathogenesis of AD, one of the most complicated and progressive neurodegenerative disease, and among them, mitochondrial dysfunction has emer...
KEY FINDING: mtDNA abnormality triggers mitochondrial dysfunction, causing inflammatory responses and microglial activation and ultimately leading to irreversible neuronal death and loss of glial function.
Frontiers in Microbiology, 2022 • September 26, 2022
This study aimed to investigate the changes in lymphocyte subsets and gut microbiota in Chinese Han patients with SCI. It enrolled 23 SCI patients and 21 healthy controls, collecting blood and fecal s...
KEY FINDING: CD4 + cells, CD4 + /CD8 + ratio and CD4 + CD8 + cells in peripheral blood of SCI patients were significantly lower than those of the control group.
Journal of Neuroinflammation, 2022 • November 8, 2022
The study investigated the connection between neuropathic pain (NP) and neuroinflammation (NIF) following spinal cord injury (SCI) in rats. The researchers explored whether NP coexists with changes in...
KEY FINDING: SCI resulted in impaired sensorimotor functions, altered reflexes, and hypersensitivity to painful stimuli.
Frontiers in Cellular Neuroscience, 2022 • November 17, 2022
Age as a biological variable affects SCI injury and recovery processes as well as responses to treatments in often unpredictable ways. Mechanisms underlying a diminished functional recovery after SCI ...
KEY FINDING: Older age at the time of SCI is associated with worse functional outcomes, even when injury severity, anatomical location, and injury type are controlled across age groups in rats and mice.
Cureus, 2022 • November 9, 2022
This prospective study assessed 36 post-ICU COVID-19 survivors who underwent inpatient rehabilitation, evaluating their functional and respiratory status at admission, discharge, and three months post...
KEY FINDING: Significant improvement in MEP, PCF, functional capacity (1STST), and 6MWT between discharge (T1) and three months after discharge (T2).
Inflammation and Regeneration, 2023 • March 1, 2023
This study investigates the role of CD8+ T cells in the differentiation of neural stem cells (NSCs) after spinal cord injury (SCI). The findings indicate that CD8+ T cells promote the differentiatio...
KEY FINDING: A prolonged increase of activated CD8+ T cells occurs in the injured spinal cords, peaking at 14 days post-injury.
Top Spinal Cord Inj Rehabil, 2023 • January 1, 2023
This study explored the association between dipstick-determined bladder inflammation, presence of nitrite, and valid and reliable urinary symptoms among people with NLUTD using indwelling catheterizat...
KEY FINDING: No association was observed between clinically actionable (A), bladder (B1), and urine quality (B2) symptoms and positive dipstick results.
Top Spinal Cord Inj Rehabil, 2023 • January 1, 2023
The study investigated risk factors and healthcare utilization costs associated with UTIs in individuals with SCI using IBM’s Marketscan Database from 2000-2019. Results showed that younger age, femal...
KEY FINDING: Younger age, female sex, thoracic level of injury, noncommercial insurance, and having at least one comorbidity were associated with increased odds of UTI.
Cell & Bioscience, 2023 • April 3, 2023
This study demonstrates that exosomes derived from vascular endothelial cells improve functional recovery and augment microglia/macrophages M2 polarization in vivo and in vitro. USP13 was highly upreg...
KEY FINDING: Exosomes derived from microvascular endothelial cells promote motor rehabilitation and M2 polarization of microglia/macrophages after SCI.