Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 351-360 of 730 results
Open Forum Infectious Diseases, 2023 • February 16, 2023
This quasi-experimental study evaluated the efficacy of short antibiotic treatment durations (5-7 days) compared to longer durations (10 days) for osteomyelitis complicating pressure ulcers in spinal ...
KEY FINDING: A 5 to 7-day antibiotic treatment following surgical debridement and flap covering appears to be a safe and effective treatment strategy for osteomyelitis complicating pressure ulcers.
Turk J Phys Med Rehab, 2023 • December 23, 2022
This study aimed to investigate T-cell activity in patients with chronic SCI, determining the effects of autonomic dysfunction and the completeness of injury at different levels on cellular immune res...
KEY FINDING: Patients with incomplete SCIs had a higher skin response to candida compared to those with complete SCIs.
Frontiers in Immunology, 2024 • August 29, 2024
This review explores the use of spatial multi-omics technologies to understand the microenvironment after traumatic spinal cord injury (tSCI). The pathological mechanism of traumatic spinal cord injur...
KEY FINDING: Single-cell RNA sequencing (scRNA-seq) has advanced understanding of the pathophysiology of spinal cord injury, offering insights into new cell types/subtypes, neuroimmunology, biological states, and their activation.
Cell Death & Disease, 2021 • April 29, 2021
This study analyzed human umbilical-cord-derived MSCs from 32 donors and found donor-dependent variations in cell proliferation and immune modulatory functions, potentially explaining inconsistent cli...
KEY FINDING: Human umbilical cord-derived MSCs from 32 donors showed donor-dependent variations in proliferation and immune modulation capabilities.
Neurochemical Research, 2023 • September 12, 2022
This study investigates the context-dependent effects of the complement peptide C3a on primary mouse astrocytes under different conditions: naive, after chemical ischemia, and after exposure to lipopo...
KEY FINDING: C3a down-regulated the expression of Gfap, C3 and Nes in astrocytes after ischemia, suggesting a reduction in reactive astrocyte markers in this context.
Frontiers in Immunology, 2021 • July 9, 2021
This study demonstrates that EV71 infection in mice leads to significant muscle tissue damage, including myositis and calcification, which contributes to limb paralysis. The research highlights the im...
KEY FINDING: EV71 infection induces severe myositis and muscle calcification in mice, contributing to limb paralysis. The muscle damage peaks at 5-7 days post-infection, followed by gradual recovery.
Int. J. Mol. Sci., 2022 • September 29, 2022
This study examined the temporal profile of circulating white blood cells during the progression of DCM in a mouse model. The research aimed to identify potential systemic hematological changes that c...
KEY FINDING: Circulating monocytes increased four-fold at 3 weeks following DCM induction, but these differences normalized at subsequent time points.
Frontiers in Cellular and Infection Microbiology, 2023 • May 5, 2023
This study investigates the pathogenic mechanisms of Prototheca wickerhamii by integrating transcriptomics, proteomics, and metabolomics data from different strains. The researchers identified that do...
KEY FINDING: Mannan endo-1,4-b-mannosidase was significantly downregulated in the mucous strain (S1) of P. wickerhamii, contributing to a thinner cell wall.
Cell Death and Disease, 2025 • January 29, 2025
The study demonstrates that the nuclear orphan receptor NR2F6 represses the expression of the activating receptor NKp46, an established key player in NK cell-mediated cytotoxicity during infection and...
KEY FINDING: NR2F6 represses the expression of the activating receptor NKp46, a key player in NK cell-mediated cytotoxicity.
Frontiers in Cellular Neuroscience, 2016 • February 9, 2016
This study challenges the dogma that the CNS is an alymphatic environment by investigating the expression of lymphatic markers LYVE-1 and PROX1 in the adult rat spinal cord. The research identified nu...
KEY FINDING: PROX1-immunoreactivity was detected in numerous nuclei evenly distributed throughout the gray and white matter of the rat adult spinal cord.