Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 331-340 of 730 results
Scientific Reports, 2020 • November 13, 2020
This study investigated the impact of C6 deficiency on spinal cord injury (SCI) recovery in PVG rats, comparing outcomes between rats from separate homozygous colonies and littermate controls. The fin...
KEY FINDING: Rats maintained as separate homozygous colonies showed improved locomotor outcome with C6 deficiency, while littermate controls exhibited impaired locomotor outcome with C6 deficiency.
Front. Syst. Neurosci., 2020 • October 15, 2020
This case report investigates the effects of prolonged cardiovascular-targeted epidural stimulation (CV-scES) on cardiovascular function and immune system modulation in an individual with chronic cerv...
KEY FINDING: Orthostatic tolerance improved significantly, from 10 minutes pre-CV-scES to the full 30 minutes post-CV-scES during a head-up tilt test.
Spinal Cord Series and Cases, 2020 • October 7, 2020
This case report describes a rare instance of a spinal epidural abscess (SEA) secondary to septic arthritis of a thoracic facet joint (SAFJ) in a 53-year-old woman, leading to spinal cord compression ...
KEY FINDING: Early diagnosis and treatment of septic arthritis of the facet joint and spinal epidural abscess are crucial to prevent severe neurological consequences.
Lancet, 2021 • January 23, 2021
Acute flaccid myelitis (AFM) is a serious, polio-like illness affecting mainly children, characterized by acute limb weakness and spinal cord gray matter abnormalities. Recent outbreaks have been link...
KEY FINDING: Enterovirus D68 is strongly linked to AFM outbreaks, supported by temporal and geographical correlations, its prevalence in AFM patients' samples, and recent strains showing increased neurovirulence in models.
International Journal of Molecular Sciences, 2021 • January 13, 2021
This paper demonstrates that chronic SCI patients without associated inflammatory and infectious diseases show functional impairment of circulating monocytes, with diminished TLR4 expression, increased...
KEY FINDING: Chronic SCI patients exhibit impaired circulating monocyte function, including diminished TLR4 expression, increased LPS-induced TNF-α production, and defective phagocytosis.
Clinical and Translational Medicine, 2021 • January 13, 2021
The study retrospectively analyzed data from 161 SCI patients admitted to Brisbane’s Princess Alexandra Hospital and validated findings with a cohort from the Trauma Hospital Berlin, Germany (n = 49)....
KEY FINDING: Acute neutrophilia in SCI patients is correlated with the New Injury Severity Score (NISS) but inversely correlated with neurological outcome (AIS grade).
Porto Biomed. J., 2019 • November 7, 2019
This retrospective study evaluated the incidence of UTI after urodynamics in patients with SCI, under fosfomycin prophylaxis, finding a 0% incidence of UTI according to NIDRR criteria. The study inclu...
KEY FINDING: The incidence of UTI, as defined by NIDRR criteria, was 0% in the study population following urodynamic studies with fosfomycin prophylaxis.
Microbiome, 2021 • March 17, 2021
This study investigated the effect of fecal microbiota transplantation (FMT) on neurological restoration in a spinal cord injury (SCI) mouse model. The results demonstrated that FMT facilitated functi...
KEY FINDING: Fecal microbiota transplantation (FMT) improved locomotor recovery in SCI mice, as indicated by increased BMS scores and improved gait parameters.
Spinal Cord Series and Cases, 2021 • February 5, 2021
This case report describes the diagnostic workup of fever of unknown origin in a 51-year-old male with multiple medical comorbidities who presented following an acute traumatic cervical spinal cord in...
KEY FINDING: The case highlights the importance of serial medical histories and physical examinations when investigating fever of unknown origin.
The Journal of Neuroscience, 2017 • November 29, 2017
The study investigates the effect of Maresin 1 (MaR1) on inflammatory resolution and neurological recovery after spinal cord injury (SCI) in mice. It was found that the biosynthesis of specialized pro...
KEY FINDING: SPM biosynthesis is impaired after SCI, with delayed synthesis of SPMs derived from AA, DHA, and EPA.