Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 261-270 of 730 results
Frontiers in Immunology, 2024 • March 13, 2024
Spinal cord injury results in tissue debris and an inflammatory microenvironment that inhibits nerve regeneration; macrophages, the primary cells for debris removal, can become foam cells, worsening i...
KEY FINDING: Foam cells persist in the lesion site after SCI and mediate chronic inflammation, which hampers nerve repair.
Frontiers in Cellular Neuroscience, 2024 • March 20, 2024
This study investigates the role of phospholipase D (PLD) in spinal cord injury (SCI) in mice, using the PLD inhibitor FIPI to assess its therapeutic potential. The results demonstrate that PLD expres...
KEY FINDING: PLD expression increases after SCI, suggesting its involvement in secondary injury processes post-SCI.
Heliyon, 2024 • April 25, 2024
This study aimed to dissect the neuroimmune-related regulatory mechanisms of SCI and OA using bioinformatics analysis. The study suggests that a miRNA-gene-pathway network is implicated in the neuroim...
KEY FINDING: A total of 185 common differentially expressed genes (DEGs) were identified in both SCI and OA.
J. Clin. Med., 2024 • May 8, 2024
Spinal cord injuries lead to debilitating neurological impairments. Microglia play a critical role in both inflammation and repair processes following SCI. Numerous therapeutic strategies targeting mi...
KEY FINDING: Microglia play a crucial role in the posttraumatic phenomena, particularly in neuroinflammation following spinal cord injury.
Neural Regen Res, 2025 • June 3, 2024
This review investigates the role of the complement system in spinal cord injury (SCI), focusing on its involvement in neuroinflammation. It discusses the sources and triggers of complement activation...
KEY FINDING: The complement system, a component of the innate immune system, plays a dual role in spinal cord injury (SCI), acting both as a recognition system and an immune effector, exacerbating primary injury and limiting functional recovery.
Scientific Reports, 2024 • June 5, 2024
This study investigated the effects of nutritional factors on the occurrence of pneumonia after cervical spinal cord injury (CSCI). The results showed that low nutritional status, severe paralysis, an...
KEY FINDING: Low nutritional status, indicated by a PNI ≤ 38.7, was a significant risk factor for pneumonia after CSCI (OR 3.35; 95% CI 1.19–9.39).
Frontiers in Immunology, 2024 • June 13, 2024
This study provides a bibliometric analysis of glial cell immunoregulation after spinal cord injury (SCI) from 2004 to 2023, identifying global research trends and hotspots. The analysis reveals that ...
KEY FINDING: The United States is the most active country in this research area, with the most publications and international collaborations.
J. Clin. Med., 2024 • July 2, 2024
This retrospective study analyzed 560 patients with spinal cord injuries to investigate the incidence of urinary tract infections (UTIs) in relation to bladder emptying methods. The study found a high...
KEY FINDING: A high percentage (71.8%) of patients developed a UTI during their rehabilitation.
Progress in Rehabilitation Medicine, 2024 • August 29, 2024
This case report describes a woman in her 30s who experienced a rapid worsening of neurological symptoms and cysto-rectal disturbances after a COVID-19 infection, leading to the diagnosis and surgical...
KEY FINDING: COVID-19 infection may exacerbate bleeding from a spinal cavernous hemangioma, leading to a rapid deterioration of neurological symptoms.
Journal of Neuroinflammation, 2024 • August 22, 2024
This study aimed to explore the roles of oligodendrocytes and their interactions with other glial cells in neuropathic pain (NP) development using a chronic constriction injury (CCI) model in mice and...
KEY FINDING: Neuropathic pain peaked on day 7 after chronic constriction injury in mice, concurrent with myelin lesions in both the spinal cord and sciatic nerve.