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  4. Microbiological profile and antibiotic susceptibility profile of urine cultures in patients with spinal cord injury—retrospective study

Microbiological profile and antibiotic susceptibility profile of urine cultures in patients with spinal cord injury—retrospective study

Porto Biomed. J., 2024 · DOI: http://dx.doi.org/10.1097/j.pbj.0000000000000272 · Published: June 1, 2024

Spinal Cord InjuryImmunologyHealthcare

Simple Explanation

This study examines urine cultures from patients with spinal cord injuries (SCI) to understand the types of infections they commonly get and how well antibiotics work against those infections. The goal is to help doctors choose the right antibiotics when treating these infections, especially since antibiotic resistance is a growing concern. The study looks at the specific germs causing the infections and their resistance to different antibiotics to guide better treatment decisions.

Study Duration
January 2016 and April 2024
Participants
29 patients with SCI
Evidence Level
Retrospective observational study

Key Findings

  • 1
    E. coli was the most common microorganism found in both UTIs and UTCs.
  • 2
    High resistance to fluoroquinolones, low resistance to cephalosporins, and very low resistance to nitrofurantoin were observed.
  • 3
    Specific multidrug-resistant organisms (MDROs) accounted for 11.2%, mostly identified in patients with indwelling catheters.

Research Summary

The study characterized the microbiological profile of urine cultures in SCI patients and determined antibiotic susceptibility profiles. E. coli was the most common microorganism, with variations based on voiding methods. The data reported can facilitate empiric antibiotic selection in selected cases.

Practical Implications

Infection Management

Understanding the common microorganisms and their antibiotic resistance can guide empiric antibiotic selection.

Catheterization Practices

Highlighting the association between catheterization and MDROs suggests a need for improved catheter management protocols.

Antibiotic Stewardship

The findings support antibiotic stewardship by emphasizing the importance of culture-directed therapy to prevent MDRO development.

Study Limitations

  • 1
    Relatively small sample size.
  • 2
    Inclusion of patients only from a single PRM outpatient consultation, potentially introducing selection bias.
  • 3
    Not specified

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