Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 221-230 of 730 results
Int. J. Mol. Sci., 2023 • May 2, 2023
This review discusses the role of cAMP-specific PDE inhibition in modulating neuroinflammation and promoting neuroregeneration following SCI in rodent models. The review highlights the potential of PD...
KEY FINDING: Inhibition of cAMP-specific PDEs, particularly PDE4, PDE7, and PDE8, shows potential in managing neuroinflammation and promoting regeneration in the central nervous system after SCI.
Nature Communications, 2022 • June 8, 2022
This study reveals that chondroitin sulfate proteoglycans (CSPGs), known inhibitors of axonal growth after spinal cord injury (SCI), also prevent inflammation resolution by blocking the conversion of ...
KEY FINDING: CSPGs impede resolution of inflammation after SCI, leading to prolonged inflammatory pathology and irreversible tissue destruction.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2021
This review examines spinal cord disorders associated with SARS-CoV-2, finding a variety of manifestations like acute transverse myelitis and acute necrotizing myelitis. The mechanisms of spinal cord ...
KEY FINDING: COVID-19-related spinal cord manifestations include acute transverse myelitis, acute necrotizing myelitis, SARS-CoV-2 myelitis, acute disseminated encephalomyelitis and others.
Annals of Medicine and Surgery, 2022 • March 1, 2022
This case report presents an instance of bullous pemphigoid developing after the second dose of the Pfizer COVID-19 vaccine in an elderly man. The patient presented with bullae and intense pruritus af...
KEY FINDING: A 78-year-old man developed bullous pemphigoid after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine.
Spinal Cord, 2024 • May 1, 2024
This qualitative study explored the knowledge, perceptions, and beliefs about UTIs among Veterans with neurogenic bladder (NB) to inform the development of person-centered interventions for improved U...
KEY FINDING: Participants showed knowledge gaps in UTI prevention, identifying specific UTI symptoms, and understanding antibiotic side effects.
Spinal Cord, 2020 • May 1, 2020
This study assessed the impact of multidrug-resistant gram-negative organisms (MDRGNOs) on outcomes in individuals with spinal cord injury/disorder (SCI/D). The results showed that having an MDRGNO cu...
KEY FINDING: MDRGNOs are prevalent in SCI/D, with 33.0% of the 8,681 individuals having a MDRGNO.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This retrospective cohort study elucidated the incidence and risk factors for pneumonia after acute traumatic cervical spinal cord injury (CSCI). The study revealed that aspiration pneumonia is common...
KEY FINDING: The incidence of pneumonia following traumatic cervical spinal cord injury was 18%, with 87% of these cases being aspiration-related.
The Journal of Spinal Cord Medicine, 2023 • June 28, 2022
This study investigated the safety and feasibility of intravesical hyaluronic acid with chondroitin sulphate (HA+CS) instillations in preventing urinary tract infections (UTIs) in patients with acute ...
KEY FINDING: HA+CS was well tolerated by participants with spinal cord injury.
Neurol Neuroimmunol Neuroinflamm, 2023 • May 1, 2023
The study provides evidence for de novo post-traumatic antibody synthesis at the spinal cord lesion site and emerging antibody-mediated autoimmunity after human SCI, directed against spinal cord and D...
KEY FINDING: A subpopulation of SCI patients (16%) developed autoantibodies that bind to spinal cord epitopes and DRG neurons, while these were absent in vertebral fracture controls.
Cureus, 2023 • March 17, 2023
This case report presents a rare instance of carpal osteomyelitis in a 62-year-old male with a spinal cord injury (SCI). The patient was successfully treated with antibiotics, avoiding surgical interv...
KEY FINDING: Carpal osteomyelitis is rare in SCI patients and can be challenging to diagnose due to nonspecific symptoms and lab markers.