Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 231-240 of 730 results
Biology, 2023 • April 19, 2023
Patients in the SCI-ECP (5 to 15 years post-injury) and SCI-LCP (>15 years post-injury) groups seemed to present an increased proportion of CD4+ CD25+/low Foxp3+ Tregs in comparison to healthy subject...
KEY FINDING: There was a significant increase in the amount of circulating CD4+ CD25+ Foxp3+ in SCI-LCP compared to HC and SCI-ECP.
Int. J. Mol. Sci., 2023 • April 11, 2023
The study demonstrates an altered profile of cytokine-producer T cells in patients with chronic SCI, with notable changes throughout the course of the disease. Significant variations in cytokine produ...
KEY FINDING: Patients with late-chronic SCI (SCI-LCP) exhibit a significant increase in the spontaneous expression of IL-10 by CD4 cells in comparison to healthy controls (HC) and SCI-SP.
Journal of Neurotrauma, 2023 • December 1, 2023
This study longitudinally profiled immunological changes in individuals with SCI during the first year post-injury, identifying dynamic molecular and cellular changes using RNA sequencing, flow cytome...
KEY FINDING: Reduced expression of NK cell genes was observed within the first 6 months post-injury, consistent with reduced frequencies of CD56bright and CD56dim NK cells at 12 months post-injury.
Military Medical Research, 2023 • June 1, 2023
This review comprehensively examines the psychoneuroimmunoendocrinology (PNIE) of spinal cord injury (SCI), emphasizing the interconnectedness of neurological, immunological, and endocrine systems in ...
KEY FINDING: SCI involves both primary injury, which is often irreversible, and secondary injury, which can be delayed and potentially treatable. Understanding the pathophysiology of secondary damage is crucial for timely specialist intervention.
Brain, 2023 • June 28, 2023
The SCIentinel study prospectively assessed the impact of spinal cord injury (SCI) on the immune system, comparing SCI patients with varying injury levels and severities to vertebral fracture (VF) pat...
KEY FINDING: SCI patients, particularly those with high and complete injuries, exhibited significantly reduced mHLA-DR expression, indicating a suppressed immune state.
Frontiers in Immunology, 2023 • June 14, 2023
This study investigates the therapeutic mechanisms of transcranial intermittent theta-burst stimulation (iTBS) on nerve regeneration and functional recovery in rats with complete spinal cord transecti...
KEY FINDING: Transcranial iTBS reduces inflammation and neuronal apoptosis in the sensorimotor cortex (SMC) following spinal cord injury.
Frontiers in Molecular Neuroscience, 2023 • July 10, 2023
This review describes the changes in IL-10 and its receptors after spinal cord injury. It further elucidates the multiple neuroprotective effects and underlying mechanisms of IL-10 in the treatment of...
KEY FINDING: IL-10 exhibits anti-oxidative stress effects by enhancing mitochondrial homeostasis, decreasing lipid peroxidation, and inhibiting the production of peroxides and inflammatory cytokines after SCI.
Biomedicines, 2023 • July 7, 2023
This study examined the microbiological burden and catheter surface changes associated with short-term reuse. Catheter surface changes and the presence of antibiotic-resistant bacteria were evident fo...
KEY FINDING: Catheter swab cultures showed no growth after 48 h (47.8%), skin flora (28.9%), mixed flora (17.8%), or bacterial growth (5.5%).
Cureus, 2023 • July 7, 2023
This study evaluated the effectiveness of telerehabilitation for individuals with spinal cord injury (SCI) during the COVID-19 pandemic. The study found that telerehabilitation interventions were safe...
KEY FINDING: The self-care and mobility domains of the SCIM III in the intervention group compared to the control group, as determined through a between-group analysis, showed statistically significant differences.
Spinal Cord Series and Cases, 2023 • January 1, 2023
This paper reports two cases of spinal cord injury (SCI) resulting from pyogenic spinal infections (PSI) caused by Staphylococcus aureus, which complicated infected atopic eczema. Both patients were t...
KEY FINDING: Both patients developed spinal cord injuries as a result of pyogenic spinal infections (PSI) caused by Staphylococcus aureus originating from infected atopic eczema.