Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 981-990 of 1,773 results
Development, Growth & Differentiation, 2022 • May 1, 2022
This study describes the development and characterization of transgenic Xenopus lines with a Cre-ERT2/loxP system for inducible and tissue-specific cell labeling. The researchers demonstrated conditio...
KEY FINDING: CAG promoter-driven Cre-ERT2/loxP system showed conditional labeling of muscle, epidermal, and interstitial cells in tadpole tails and froglet legs upon 4OHT treatment.
Biotechnology Advances, 2022 • May 16, 2022
Extracellular vesicles (EVs), particularly exosomes, hold promise for treating various diseases and promoting tissue regeneration. However, current production methods suffer from low yield and scalabi...
KEY FINDING: Mechanical loading, such as shear stress or cyclic tension, can significantly increase EV secretion, potentially by over 100-fold.
J Mol Endocrinol, 2022 • November 1, 2022
Retinoic acid (RA) signaling, mediated by nuclear RA receptors (RARs), is crucial for embryonic development. RA's role was discovered through observations of its teratogenic effects and later confirme...
KEY FINDING: RA signaling is required for normal early development of many organs and tissues, including the hindbrain, posterior body axis, somites, spinal cord, forelimbs, heart, and eye.
Pharmaceuticals, 2022 • April 25, 2022
This study investigates the regulatory action of miR-182-5p on Nogo-A, a myelin-associated inhibitor of axonal regeneration. The research demonstrates that miR-182-5p downregulates Nogo-A protein expr...
KEY FINDING: miR-182-5p mimic specifically downregulates the expression of the luciferase reporter gene fused to the mouse Nogo-A 3′UTR, and Nogo-A protein expression in Neuro-2a and C6 cells.
Cell Communication and Signaling, 2022 • April 30, 2022
This study identifies and characterizes a novel natural antisense RNA, Foxk1-AS, which is transcribed from the opposite strand of the Foxk1 gene. Foxk1-AS is found to be located within the 3' UTR of F...
KEY FINDING: Foxk1-AS is a natural antisense RNA transcribed from the opposite strand of the Foxk1 gene and is completely incorporated in the 3′ UTR of Foxk1.
Dev Biol, 2022 • August 1, 2022
This study demonstrates that post-synaptic dendrites in the vertebrate spinal cord (zebrafish) can regenerate after injury, expanding the understanding of neuronal regeneration capabilities. The resea...
KEY FINDING: Zebrafish motor neurons are capable of regenerating dendrites after laser microsurgery, even when all dendrites are removed.
Frontiers in Cellular Neuroscience, 2022 • May 20, 2022
Perineuronal nets (PNNs) are specialized extracellular matrix structures that play a critical role in modulating plasticity and stability in the central nervous system. Following spinal cord injury (S...
KEY FINDING: Spinal PNNs differ from cortical PNNs in composition, modulation, and the types of neurons they surround, suggesting distinct roles in the spinal cord.
Frontiers in Neurology, 2022 • May 20, 2022
Spinal Cord Injury (SCI) is a serious condition with limited effective treatments, often resulting in inflammation, apoptosis, autophagy, and oxidative stress. The mTOR signaling pathway plays a key r...
KEY FINDING: Quercetin has antioxidant and anti-inflammatory properties, promotes autophagy, and inhibits apoptosis, making it a potential drug for SCI.
Frontiers in Immunology, 2022 • May 30, 2022
The study characterized two populations of intraperitoneal zymosan-modulated Ly6G+ neutrophils, revealing that 3d NF exhibit features of alternative activation, an immature stage of development, and n...
KEY FINDING: 3d NF expressed markers of alternative activation and possess neuroprotective/ regenerative properties.
J. Dev. Biol, 2022 • June 1, 2022
This study characterized ependymal cells from the trunk spinal cord of the leopard gecko, revealing a heterogenous population including radial glia and neuronal-like cells. The researchers determined ...
KEY FINDING: Ependymal cells of the trunk spinal cord express SOX2, indicating their potential as neural stem/progenitor cells.