Genetics Research

KEY FINDING: The maturation of specific cell types and neuronal populations is highlighted, including principal neurons of the primary motor cortex layer V, 'immature' neurons in the piriform cortex, and GABA-expressing inhibitory neurons of the cerebral cortex.

KEY FINDING: High-quality genome assembly of Moniezia expansa reveals potential target molecules for treating parasitic diseases through the identification of specific fatty acid metabolism and reproductive stem cell regulatory networks.

KEY FINDING: Knockdown of TWEAK and NF-κB inhibited secretion of high levels of TNF-α/IL-1β, partially counteracted by adding Rap.

KEY FINDING: MiR-17 expression is decreased in osteoarthritic chondrocytes, and its deficiency contributes to OA progression.

KEY FINDING: EGF treatment facilitates the Sox10-induced transformation of astrocytes to ­O4+ induced oligodendrocyte precursor cells (iOPCs) in vitro.

KEY FINDING: Wnt signaling is necessary for the early stages of limb bud outgrowth. Treatment with C59 at stage 40 permanently inhibited limb development.

KEY FINDING: Regeneratively competent species predominantly display apoptotic, as opposed to necrotic, cell death following a CNS injury. Notably, necrosis stimulates a pro-inflammatory immune response that leads to further damage, whereas apoptosis is typically anti-inflammatory.

KEY FINDING: The ErbB gene family evolved through Egfr duplication in ancient vertebrates but diverged after gnathostome speciation.

KEY FINDING: LMWP overcomes the neurite outgrowth inhibition by CSPGs in vitro, mimicking the effects of HB-GAM.

KEY FINDING: RAG and ATF genes are differentially expressed in early differentiated neurons versus undifferentiated neurospheres, with ATF3 showing the highest difference in expression.