Genetics Research

KEY FINDING: Early apoptosis and autophagy after TSCI protect against injury; prolonged inflammation leads to accumulation of pro-inflammatory factors and excessive apoptosis, aggravating TSCI.

KEY FINDING: Peripherally delivered gene therapies show potential as treatments for spinal cord disorders.

KEY FINDING: Mid1 is upregulated in the spinal motor neurons of SBMA mice and in samples from SBMA patients.

KEY FINDING: Continual deletion of microglia, especially during scar formation, leads to a decrease in microglia-derived collagen I and reforms the astrocyte scar.

KEY FINDING: Huc-MSCs-derived exosomes alleviated mechanical allodynia and thermal hyperalgesia in CFA-induced inflammatory pain model.

KEY FINDING: GDF15 was significantly increased in neuronal ferroptosis and silencing GDF15 aggravated ferroptosis both in vitro and in vivo, suggesting a protective role.

KEY FINDING: Adult neurons in culture from various brain regions retained several features characteristic of their in vivo cell morphology, including distinct morphologies for motor cortex, cerebellar Purkinje, hippocampal, reticulospinal, and spinal cord alpha motor neurons.

KEY FINDING: MiR-7b-3p, upregulated after SCI, targets Wipf2, protecting cortical neurons from apoptosis and maintaining plasticity.

KEY FINDING: REST acts as an upstream suppressor of the intrinsic regenerative program in the CNS.

KEY FINDING: Four PGRN genes were identified in lampreys: one long form (Lr-PGRN-L) and three short forms (Lr-PGRN-S1, Lr-PGRN-S2, and Lr-PGRN-S3).