Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 891-900 of 1,773 results
Nucleic Acids Research, 2021 • August 7, 2021
The study identifies six new ApiAP2 transcription factors associated with gametocytogenesis in Plasmodium falciparum, with PfAP2-G5 being indispensable. PfAP2-G5 acts as a repressor of the pfap2-g gen...
KEY FINDING: PfAP2-G5 suppresses the transcriptional activity of the pfap2-g gene via binding to both the upstream region and exonic gene body, preventing initiation of sexual commitment.
J Neuroinflammation, 2021 • July 11, 2021
The study investigates the potential of Schwann cell-derived exosomes (SCDEs) to promote functional recovery after spinal cord injury (SCI) in mice. SCDEs treatment increases Toll-like receptor 2 (TLR...
KEY FINDING: SCDEs treatment promotes functional recovery and induces TLR2 expression on astrocytes while decreasing CSPGs deposition post-SCI.
The Journal of Neuroscience, 2021 • September 29, 2021
This study investigates the role of Akt in oligodendrocyte (OL) development using OL lineage cell-specific Akt triple-conditional knock-out (Akt cTKO) mice. The researchers found that loss of total Ak...
KEY FINDING: Deletion of Akt three isoforms in oligodendrocyte lineage cells causes a complete loss of mature oligodendrocytes in the CNS.
Glia, 2021 • December 1, 2021
The study investigates the expression and function of glutamine synthetase (GS) in oligodendrocytes (OL) of the mouse and human spinal cord. The researchers found that GS is expressed in mature OL but...
KEY FINDING: GS is expressed in myelinating oligodendrocytes (OL) but not oligodendrocyte progenitor cells in the mouse and human ventral spinal cord.
Journal of Orthopaedic Translation, 2021 • June 9, 2021
Spinal cord injury results in permanent neurological impairments and carries a heavy socioeconomic burden. Accurately pathogenic mechanism and promising therapeutic targets remain unclear. CircRNAs ex...
KEY FINDING: Dysregulated circRNAs after SCI are enriched in neuronal signal transduction and inflammatory response.
BIOENGINEERED, 2021 • August 23, 2021
This study identifies alternative splicing events associated with bladder cancer bone metastasis and constructs a predictive model for prognosis. The research proposes a regulatory mechanism involving...
KEY FINDING: Alternative splicing events (ASEs) are associated with the occurrence and progression of bladder cancer and have a relationship with its prognosis.
Stem Cell Res Ther, 2021 • September 27, 2021
This study aimed to investigate the therapeutic effects of basic fibroblast growth factor (bFGF)-overexpressing human umbilical cord-derived mesenchymal stem cells (HUCMSCs) in mice with completely tr...
KEY FINDING: bFGF-overexpressing HUCMSCs met the standards and safety of MSCs for clinic use, indicating their potential for clinical translation.
Advanced Genetics, 2021 • May 3, 2021
Regeneration varies across the animal kingdom, with simpler vertebrates exhibiting greater regenerative capabilities than complex vertebrates. The review focuses on appendage, spinal cord, and heart r...
KEY FINDING: Nerves play a crucial role in organ regeneration across diverse species, influencing progenitor cell proliferation and differentiation through the production of promoting factors, suggesting an evolutionarily conserved role of nerves in regeneration across vertebrates.
Advanced Science, 2022 • March 6, 2022
This study developed an exosome-loaded electroconductive hydrogel (GMPE) composed of gelatin methacrylate and polypyrrole. The GMPE hydrogel was shown to reduce early inflammation, enhance neural stem...
KEY FINDING: Exosomes-loaded electroconductive hydrogels modulated microglial M2 polarization via the NF-𝜿B pathway.
Cells, 2021 • August 16, 2021
Spinal cord injury (SCI) presents a multifaceted pathophysiology, necessitating therapies that target various cellular and molecular mechanisms. Both biomaterials and lentiviral vectors (LVs) have dem...
KEY FINDING: Combining LVs with biomaterials enhances spatial control over LV delivery compared to bolus injection, improving transduction efficiency by placing the vector directly in the cell microenvironment.