Genetics Research

KEY FINDING: sEVs released by MSCs in vivo traffic to the injury site and are specifically associated with M2 macrophages.

KEY FINDING: MG-Exo treatment significantly decreased the level of oxidative stress (ROS) in vitro and in vivo when cells were exposed to H2O2-induced oxidative stress.

KEY FINDING: Nuclear epigenome affects mitochondrial function, influencing diseases like Alzheimer’s, Parkinson’s, Huntington’s, and ALS.

KEY FINDING: Immune system activation and subsequent pyroptosis occur in the early stages (6-24 hours) of AMI in a mouse model.

KEY FINDING: The study demonstrates that type A pericytes are the primary source of scar-forming fibroblasts across various CNS lesions in mice, including spinal cord injury, traumatic brain injury, ischemic stroke, and multiple sclerosis.

KEY FINDING: Dorsal and ventral telencephalons share common developmental programs during neurogenesis, following a conserved trajectory from radial glial cells (RGs) to intermediate progenitor cells (IPCs_div) and then to early neuroblasts (eNBs).

KEY FINDING: Microglia and astrocytes gather at the lesion border after spinal cord injury, with microglia closely adjacent to astrocytes.

KEY FINDING: Tuatara tail regeneration is a slow process that combines regeneration and growth (“regengrow”), resulting in tails with a cartilaginous axis, connective tissue, fat cells, and sparse nerves.

KEY FINDING: iPSC-based disease models have been studied for cardiac channelopathies including hereditary long QT syndrome (LQTS), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC).

KEY FINDING: Epidermis-specific deletion of DNMT1 disrupts epidermal structure and homeostasis, initiating a massive innate immune response and infiltration of immune cells.