Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 881-890 of 1,773 results
Frontiers in Molecular Neuroscience, 2021 • June 3, 2021
This study used both in vitro and in vivo models to investigate the response of axonal mitochondria to axonal injury. Mitochondria within CST axons undergo rapid fragmentation following severing. Inju...
KEY FINDING: Spinal cord injury decreases the length of axonal mitochondria in CST neurons of adult Sprague–Dawley rats. At 2 h following injury, mitochondria closest to the site of injury exhibited decreased length.
Stem Cell Reports, 2021 • July 13, 2021
This study demonstrates that activation of endogenous genes Ngn2 and Isl1 by CRISPRa enabled reprogramming of mouse spinal astrocytes and embryonic fibroblasts to motor neurons. These induced neurons s...
KEY FINDING: Activation of endogenous Ngn2 and Isl1 via CRISPRa successfully reprogrammed mouse spinal astrocytes and embryonic fibroblasts into motor neurons in vitro.
npj Regenerative Medicine, 2021 • July 2, 2021
This study demonstrates that adult X. tropicalis can regenerate heart tissue after ventricular apex resection, primarily through cardiomyocyte proliferation. RNA-seq analysis identified Fosl1 as a key...
KEY FINDING: Cardiomyocyte proliferation greatly contributes to heart regeneration in adult X. tropicalis upon apex resection.
Front. Neuroanat., 2021 • June 23, 2021
This article reviews the evidence for a role of Reissner's fiber (RF) in the origin of fundamental innovations of the chordate body plan, especially the elongation of the neural tube and maintenance o...
KEY FINDING: RF is a highly conserved structure in chordates, suggesting it plays a fundamental role.
Frontiers in Cell and Developmental Biology, 2021 • July 7, 2021
Extracellular vesicles are beneficial tools for delivering biomolecules in regenerative medicine, with a lower risk of complications compared to cell therapy. MSCs are a favorable source for cell-base...
KEY FINDING: Mesenchymal stem cell-derived exosomes can reduce infarct size in myocardial ischemia/reperfusion injury, implicating them in tissue repair.
EMBO Reports, 2021 • July 29, 2021
This study investigates the role of Regulator of Cell Cycle (RGCC) in neural stem cell (NSC) self-renewal and differentiation during neocortical development. The researchers found that RGCC is exclusi...
KEY FINDING: RGCC is exclusively expressed in NSCs in the developing mammalian neocortex.
eNeuro, 2021 • July 29, 2021
The study demonstrates that miR-21 and miR-199a-3p regulate axon growth by modulating the PTEN/mTOR pathway, which affects protein synthesis in neurons. Injury-induced alterations in miR-21 and miR-19...
KEY FINDING: miR-21 increases and miR-199a-3p decreases in DRG neurons after in vivo axotomy, suggesting injury-induced changes in these miRs.
The Journal of Neuroscience, 2021 • September 22, 2021
This study investigates the role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channels in oligodendrocytes, focusing on their impact on myelin sheath length. The researchers found...
KEY FINDING: Oligodendrocytes abundantly express functional, predominantly HCN2 subunit-containing ion channels, which retain key pharmacological and biophysical features.
Exp Neurol., 2021 • November 1, 2021
This study demonstrates that lentivirus-mediated Nkx6.1 expression promotes cell proliferation and activation of endogenous NSPCs, which correlates with a transient upregulation of the Notch signaling...
KEY FINDING: Nkx6.1 expression increases NSPC activation and proliferation in the acute phase of SCI.
International Journal of Molecular Sciences, 2021 • August 3, 2021
This review explores the mechanisms of growth cone guidance and canonical guidance cues, comparing pathfinding after axotomy in regenerative and non-regenerative animal models. Guidance cues play a cr...
KEY FINDING: Growth cones are specialized structures that guide axon growth by sensing the environment and regulating the cytoskeleton through guidance cues.