Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 621-630 of 1,773 results
Anesth Analg, 2022 • July 1, 2022
This study demonstrates that spinal cord stimulation (SCS) can alleviate neuropathic pain in rats by inhibiting the transmission of colony-stimulating factor 1 (CSF1) from the dorsal root ganglion (DR...
KEY FINDING: SCS significantly increased the mechanical withdrawal threshold in CCI rats, indicating pain relief.
Cells, 2022 • June 9, 2022
Microglia play a very important role in normal physiological processes and after SCI. Following SCI, on the one hand, microglia respond quickly and play a certain role in neuroprotection and repair by...
KEY FINDING: Sustained microglial depletion would aggravate injury and impair functional recovery after spinal cord injury.
Disease Markers, 2022 • June 20, 2022
The study demonstrates that perineural administration of DEX can alleviate neuropathic pain in mice by activating the AMPK pathway. DEX's beneficial effects involve the restoration of mitochondrial fu...
KEY FINDING: Perineural DEX significantly reversed the decline in mechanical threshold and thermal latency in CCI mice, indicating pain relief.
Frontiers in Endocrinology, 2022 • June 20, 2022
This study investigates the interaction between melanocortin 1 receptor (Mc1r) and melanocortin receptor-associated proteins (Mraps) in Xenopus tropicalis. The research combines in silico analysis wit...
KEY FINDING: xtMc1r interacts directly with xtMrap1 and xtMrap2 proteins on the plasma membrane, validated through co-immunoprecipitation and fluorescence.
Adv. Healthcare Mater., 2022 • August 25, 2022
The study addresses the challenge of delivering therapeutic proteins, specifically ChABC, to spinal cord injuries (SCIs) due to their instability. It explores a non-viral mRNA-based method using miner...
KEY FINDING: MCM-mediated mRNA delivery is an efficient non-viral gene delivery method in primary neural cells in vitro and enabled localized transgene expression in the glial scar in vivo.
Cells, 2022 • July 18, 2022
This study used RNA sequencing to analyze gene expression changes in rats at five time points after spinal cord injury (SCI): 1 hour, 1 day, 1 week, 1 month, and 3 months. The researchers identified d...
KEY FINDING: The inflammatory response was increased at 1 hour and 1 day after SCI, while the integral component of the synaptic membrane was increased at 1 day.
PeerJ, 2022 • July 29, 2022
This study investigates the effects of exercise therapy on spinal cord injury (SCI) in rats by analyzing the expression of lncRNAs, miRNAs, and mRNAs using RNA-seq technology. The research identifies ...
KEY FINDING: The study identified 76 differentially expressed lncRNAs (DELs), 33 differentially expressed miRNAs (DEMs), and 30 differentially expressed genes (DEGs) between SCI rats and exercise therapy rats.
Cell & Bioscience, 2022 • August 1, 2022
This study investigates the role of D-dopachrome tautomerase (D-DT), a homolog of macrophage migration inhibitory factor (MIF), in astroglial inflammation following spinal cord injury (SCI). It aims t...
KEY FINDING: D-DT protein levels were significantly elevated within neurons and astrocytes following SCI, suggesting these cell types are crucial sources of D-DT production following SCI.
PeerJ, 2022 • August 16, 2022
This study aimed to investigate the effect of Sema3A/NRP1 signaling in oligodendrocytes (OLs) after spinal cord injury (SCI) in rats. Bioinformatics analysis and experimental validation were used to e...
KEY FINDING: After SCI, significantly fewer oligodendrocytes were observed, while NRP1 and its ligand Sema3A were upregulated.
EMBO Reports, 2021 • August 24, 2021
This study investigates the role of Foxm1, a transcription factor, in spinal cord regeneration in Xenopus tropicalis tadpoles using bulk and single-cell RNA sequencing. The research finds that Foxm1 i...
KEY FINDING: Foxm1 is specifically expressed in the regenerating spinal cord of Xenopus tadpoles, peaking at 3 days post-amputation.