Genetics Research

KEY FINDING: A significant positive relationship was observed between PBMC and permeabilized skeletal muscle for mitochondrial complex IV (r = 0.86, P < 0.0001), indicating that PBMC measurements can reflect muscle mitochondrial function for this specific complex.

KEY FINDING: The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction.

KEY FINDING: Thrombin reverses astrocytic stellation, promoting proliferation but inhibiting migration.

KEY FINDING: Hsa_circ_0026646 was identified as a core circRNA upregulated in SCI, potentially acting as a 'molecular sponge' for miR-331-3p.

KEY FINDING: At the respiratory level, tissue damage is notable in situations that require increased ventilation due to lower thoracic distensibility and alveolar inflammation caused by higher levels of leptin as a result of increased fatty tissue.

KEY FINDING: FMT treatment significantly improved spinal cord tissue sparing, vascular perfusion, and BSCB integrity in SCI mice.

KEY FINDING: Nine phages were identified that individually decreased cell viability by >80% when added to biofilms of two E. coli strains in human urine.

KEY FINDING: Notch1 mRNA expression trended toward a significant increase from Pre to 2 Days post-muscle damage from baseline measures (p = 0.087).

KEY FINDING: Overexpression of FANCC suppressed microglial pyroptosis by inhibiting p38/NLRP3 expression, which in turn reduced neuronal apoptosis.

KEY FINDING: Sodium selenite treatment decreased iron concentration and levels of the lipid peroxidation products malondialdehyde and 4-hydroxynonenal in a rat model of spinal cord injury.