Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 631-640 of 1,773 results
Cells, 2022 • August 11, 2022
This systematic review examines the involvement of key cations (Na+, K+, Li+, Ca2+, Mg2+, Fe, Zn) in the cellular biology of traumatic spinal cord injury (tSCI). The review synthesizes data on biochem...
KEY FINDING: Following spinal cord injury, primary mechanical trauma can cause cell swelling and lysis, increasing the extracellular Ca2+ concentration, leading to excitotoxicity.
Molecular Medicine, 2022 • September 12, 2022
miR-21 has potential against the burden of SCI through suppressing the inflammatory milieu in neural cells, apoptosis inhibition, improving angiogenesis, and synapsis protection. Current understanding...
KEY FINDING: miR-21 overexpression reduces neuroinflammation after SCI by decreasing the expression of inflammatory factors.
The Journal of Spinal Cord Medicine, 2020 • July 1, 2020
This study investigated the safety of fenofibrate therapy in persons with SCI to determine the safety profile of 4 months of once-daily fenofibrate treatment when initiated using modified intervention...
KEY FINDING: Four out of 15 participants experienced an adverse event, including gastrointestinal distress and elevated liver enzymes, leading to three subjects discontinuing the medication.
The Journal of Spinal Cord Medicine, 2020 • January 1, 2020
Skeletal muscle mitochondrial activity is reduced by ∼50–60% after SCI, resulting in impaired energy expenditure, glucose utilization and insulin sensitivity. Near infra-red spectroscopy (NIRS) is a n...
KEY FINDING: Only four participants produced data with accepted rate constants of 0.002–0.013 s−1 and r2 of 0.71–0.87.
Nature Communications, 2019 • September 13, 2019
This study identifies circAnks1a as a key regulator in neuropathic pain, showing its expression is increased following nerve injury in a rodent model. Reducing circAnks1a levels alleviates pain-like b...
KEY FINDING: Spinal nerve ligation increases circAnks1a expression in dorsal horn neurons.
Spinal Cord, 2020 • March 1, 2020
This study demonstrates that rapid bone loss occurs as early as 2 days after a complete spinal cord injury (SCI) in rats. The researchers found a decrease in bone mass and deterioration of bone micros...
KEY FINDING: Neurologically motor-complete SCI causes loss of bone mass and deterioration of trabecular bone microstructure as early as 2 days after injury.
J Cell Mol Med, 2020 • January 1, 2020
This study investigates the effects of low-level laser therapy (LLLT) on macrophage polarization and neurotrophic factor secretion in an in vitro model of spinal cord injury (SCI). The results demonst...
KEY FINDING: LLLT irradiation decreased the expression of M1 macrophage-specific markers and increased the expression of M2 macrophage-specific markers in vitro.
Scientific Reports, 2019 • November 5, 2019
This study evaluated the efficacy of fenofibrate monotherapy on the lipoprotein profile of persons with SCI. The intervention had a robust effect to produce favorable changes to the serum TG, HDL-C an...
KEY FINDING: Fenofibrate treatment resulted in a 40% reduction in serum triglyceride (TG) concentration after both 2 and 4 months.
International Journal of Molecular Sciences, 2019 • November 27, 2019
The study aimed to investigate gene expression changes related to cell cycle activation in patients with spinal cord injury (SCI) and to further evaluate the difference between the upper and lower limb...
KEY FINDING: Cell proliferation was significantly increased in the upper limbs of SCI patients compared to the lower limbs and healthy subjects.
Cells, 2019 • December 6, 2019
This study investigates the therapeutic potential of dabrafenib, a B-RAFV600E inhibitor, in attenuating RIPK3-mediated necroptosis and promoting functional recovery after spinal cord injury (SCI) in a...
KEY FINDING: Dabrafenib administration significantly inhibited RIPK3-mediated necroptosis in the injured spinal cord, reducing the expression of RIPK3 and phosphorylated MLKL (pMLKL).